2889348-10-9
Chemical Structure
GLP-1R modulator-2
- CAS No.: 2889348-10-9
- Formula:C23H21N5
- Molecular Weight:367.45
InChIKey: MAEBITZIPYNTQM-UHFFFAOYSA-N
SMILES: CC(C1=CNC2=C1C=CC=C2)(C)CN3N=NC(C4=C5C=CC=CC5=NC=C4)=C3
Biological Activity: GLP-1R modulator-2 is a GLP-1R positive allosteric modulator with an EC50 of 106 nM. GLP-1R modulator-2 simultaneously binds to the extracellular pocket of GLP-1R and the peptide ligand GLP-1 (9-36) through a molecular glue-like allosteric effect, and selectively enhances GLP-1 (9-36)-induced G protein-dependent cAMP signaling. When used in combination with GLP-1 (9-36) under high-glucose conditions, GLP-1R modulator-2 enhances glucose-dependent insulin secretion in wild-type rat pancreatic islets. GLP-1R modulator-2 exhibits strong probe dependence and significantly potentiates the activity of GLP-1 (9-36). GLP-1R modulator-2 can be used for research on type 2 diabetes and obesity [1].
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GLP-1R modulator-2 | GLP-1R modulator-2 is a GLP-1R positive allosteric modulator with an EC50 of 106 nM. GLP-1R modulator-2 simultaneously binds to the extracellular pocket of GLP-1R and the peptide ligand GLP-1 (9-36) through a molecular glue-like allosteric effect, and selectively enhances GLP-1 (9-36)-induced G protein-dependent cAMP signaling. When used in combination with GLP-1 (9-36) under high-glucose conditions, GLP-1R modulator-2 enhances glucose-dependent insulin secretion in wild-type rat pancreatic islets. GLP-1R modulator-2 exhibits strong probe dependence and significantly potentiates the activity of GLP-1 (9-36). GLP-1R modulator-2 can be used for research on type 2 diabetes and obesity . | |||||||||||||||||||||
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