885044-59-7
Chemical Structure
Steviol glucuronide
- CAS. Nr.: 885044-59-7
- Formula:C26H38O9
- Molecular Weight:494.57
InChIKey: UWKMRMSZJBDGGY-MKXZEIDCSA-N
SMILES: [H][C@@]12CC[C@](O)(C3)C(C[C@]31CC[C@@]4([C@](C)(C(O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)C(O)=O)O)O)O)=O)CCC[C@]42C)[H])=C
Biological Activity: Steviol glucuronide is a metabolite of Steviol (HY-N2057). Steviol glucuronide upregulates Glucagon receptor transcription and downregulates β-2-microglobulin transcription. Steviol glucuronide scavenges hydroxyl/superoxide radicals and reduces thiobarbituric acid reactive substances, without DPPH/nitric oxide scavenging activity. Steviol glucuronide stimulates glucose-dependent insulin secretion and does not affect basal insulin under low-glucose conditions. Steviol glucuronide enters cells via passive diffusion and OAT3/OATP1B1/OATP1B3/OATP2B1-mediated uptake, and inhibits OATP1B1/OATP1B3-mediated transport of Rosuvastatin (HY-17504B). Steviol glucuronide can be used in research on type 2 diabetes[1][2][3][4].
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Steviol glucuronide | Steviol glucuronide is a metabolite of Steviol (HY-N2057). Steviol glucuronide upregulates Glucagon receptor transcription and downregulates β-2-microglobulin transcription. Steviol glucuronide scavenges hydroxyl/superoxide radicals and reduces thiobarbituric acid reactive substances, without DPPH/nitric oxide scavenging activity. Steviol glucuronide stimulates glucose-dependent insulin secretion and does not affect basal insulin under low-glucose conditions. Steviol glucuronide enters cells via passive diffusion and OAT3/OATP1B1/OATP1B3/OATP2B1-mediated uptake, and inhibits OATP1B1/OATP1B3-mediated transport of Rosuvastatin (HY-17504B). Steviol glucuronide can be used in research on type 2 diabetes. | |||||||||||||||||||||
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Steviol glucuronide-13C,d2 | Steviol glucuronide-13C,d2 is the 13C,d2-labeled Steviol glucuronide (HY-188367). Steviol glucuronide is a metabolite of Steviol (HY-N2057). Steviol glucuronide upregulates Glucagon receptor transcription and downregulates β-2-microglobulin transcription. Steviol glucuronide scavenges hydroxyl/superoxide radicals and reduces thiobarbituric acid reactive substances, without DPPH/nitric oxide scavenging activity. Steviol glucuronide stimulates glucose-dependent insulin secretion and does not affect basal insulin under low-glucose conditions. Steviol glucuronide enters cells via passive diffusion and OAT3/OATP1B1/OATP1B3/OATP2B1-mediated uptake, and inhibits OATP1B1/OATP1B3-mediated transport of Rosuvastatin (HY-17504B). Steviol glucuronide can be used in research on type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Gu W, et al. Steviol glucuronide, a metabolite of steviol glycosides, potently stimulates insulin secretion from isolated mouse islets: Studies in vitro. Endocrinology, diabetes & metabolism. 2019 Oct;2(4):e00093.
- [2]. Hajihashemi S, et al. Free radical scavenging activity of steviol glycosides, steviol glucuronide, hydroxytyrosol, metformin, aspirin and leaf extract of Stevia rebaudiana[J]. Free Radicals and Antioxidants, 2013, 3: S34-S41.
- [3]. Geuns JM, et al. Identification of steviol glucuronide in human urine. Journal of agricultural and food chemistry. 2006 Apr 05;54(7):2794-8.
- [4]. Wang M, et al. Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. Food Chem Toxicol. 2015 Dec;86:217-24.
