2. Signaling Pathways
  3. GPCR/G Protein
  4. GCGR
  5. GCGR Modulator

GCGR Modulator

GCGR Modulators (8):

Cat. No. Product Name Effect Purity
  • HY-124622
    NNC-0640
    		Modulator 98.10%
    NNC-0640 is a potent human G-protein-coupled glucagon receptor (GCGR) negative allosteric modulator (NAM) with an IC50 of 69.2 nM.
  • HY-116819A
    VU0453379 hydrochloride
    		Modulator ≥99.0%
    VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.
  • HY-141839
    GLP-1R modulator C16
    		Modulator 99.60%
    GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).
  • HY-142162
    LSN3318839
    		Modulator 99.81%
    LSN3318839 is an orally efficacious positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R).
  • HY-141842
    GLP-1R modulator L7-028
    		Modulator 98.77%
    GLP-1R modulator L7-028 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM).
  • HY-141840
    GLP-1R modulator C5
    		Modulator 99.60%
    GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM).
  • HY-116819
    VU0453379
    		Modulator ≥98.0%
    VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.
  • HY-124803
    GPCR modulator-1
    		Modulator
    GPCR modulator-1 is a negative allosteric modulator of GLP receptor. GPCR modulator-1 has the potential for type 2 diabetes research.