2. Signaling Pathways
  3. GPCR/G Protein
  4. GCGR
  5. GCGR Modulator

GCGR Modulator

GCGR Modulators (8):

Cat. No. Product Name Effect Purity
  • HY-124622
    NNC-0640
    		Modulator 98.43%
    NNC-0640 is an effective negative allosteric modulator (NAM) of the human glucagon receptor (GCGR), with an IC50 value of 69.2 nM. NNC-0640 holds potential for research in the field of diabetes.
  • HY-142162
    LSN3318839
    		Modulator 99.22%
    LSN3318839 is an orally active positive modulator of the glucagon-like peptide-1 receptor (GLP-1R). LSN3318839 can increase the secretion of insulin and has the effect of lowering blood sugar.
  • HY-116819
    VU0453379
    		Modulator 98.0%
    VU0453379 is a blood-brain barrier permeable GLP-1R positive allosteric modulator (PAM) with an EC50 value of 1.3 μM. VU0453379 potentiates the actions of endogenous GLP-1 and synthetic peptide agonists, and promotes GLP-1 receptor internalization. VU0453379 stimulates insulin secretion from primary mouse islets. VU0453379 enhances the function of endogenous GLP-1R and reverses catalepsy in animal models. VU0453379 is useful for research on Parkinson's disease and type 2 diabetes.
  • HY-141840
    GLP-1R modulator C5
    		Modulator 99.81%
    GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM).
  • HY-141842
    GLP-1R modulator L7-028
    		Modulator 99.47%
    GLP-1R modulator L7-028 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM).
  • HY-141839
    GLP-1R modulator C16
    		Modulator 98.67%
    GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).
  • HY-124803
    GPCR modulator-1
    		Modulator
    GPCR modulator-1 is a negative allosteric modulator of the GLP-1 receptor (GLP-1R). GPCR modulator-1 can be used for the study of type 2 diabetes.
  • HY-116819A
    VU0453379 hydrochloride
    		Modulator 99.0%
    VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.