GLP-1R modulator C16

Cat. No.: HY-141839 Purity: 99.60%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC₅₀ 8.43 ± 3.82 μM).

For research use only. We do not sell to patients.

GLP-1R modulator C16 Chemical Structure

CAS No. : 875005-43-9

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC₅₀ 8.43 ± 3.82 μM).

Molecular Weight

408.89

Formula

C₂₁H₂₆ClFN₂O₃

CAS No.

875005-43-9

Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C=CC(CNCCN2CCOCC2)=C1)OCC3=C(C=CC=C3Cl)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (122.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4456 mL	12.2282 mL	24.4565 mL
5 mM	0.4891 mL	2.4456 mL	4.8913 mL
10 mM	0.2446 mL	1.2228 mL	2.4456 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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μL

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (246 KB) HNMR (152 KB) RP-HPLC (152 KB) LCMS (242 KB)

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. ACS Chem Biol. 2021 Nov 19;16(11):2444-2452. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4456 mL	12.2282 mL	24.4565 mL	61.1411 mL
	5 mM	0.4891 mL	2.4456 mL	4.8913 mL	12.2282 mL
	10 mM	0.2446 mL	1.2228 mL	2.4456 mL	6.1141 mL
	15 mM	0.1630 mL	0.8152 mL	1.6304 mL	4.0761 mL
	20 mM	0.1223 mL	0.6114 mL	1.2228 mL	3.0571 mL
	25 mM	0.0978 mL	0.4891 mL	0.9783 mL	2.4456 mL
	30 mM	0.0815 mL	0.4076 mL	0.8152 mL	2.0380 mL
	40 mM	0.0611 mL	0.3057 mL	0.6114 mL	1.5285 mL
	50 mM	0.0489 mL	0.2446 mL	0.4891 mL	1.2228 mL
	60 mM	0.0408 mL	0.2038 mL	0.4076 mL	1.0190 mL
	80 mM	0.0306 mL	0.1529 mL	0.3057 mL	0.7643 mL
	100 mM	0.0245 mL	0.1223 mL	0.2446 mL	0.6114 mL