2. GPCR/G Protein
  3. GCGR
  4. GPCR modulator-1

GPCR modulator-1 is a negative allosteric modulator of the GLP-1 receptor (GLP-1R). GPCR modulator-1 can be used for the study of type 2 diabetes.

For research use only. We do not sell to patients.

GPCR modulator-1

GPCR modulator-1 Chemical Structure

CAS No. : 1407592-99-7

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GPCR modulator-1 Related Antibodies

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Description

GPCR modulator-1 is a negative allosteric modulator of the GLP-1 receptor (GLP-1R). GPCR modulator-1 can be used for the study of type 2 diabetes[1].

In Vitro

GPCR modulator-1 (PF-06372222) can effectively inhibit the cAMP accumulation caused by GLP-1 stimulation in HEK-293T cells expressing wild-type GLP-1R. Its pIC50 value is 5.15. After mutations at C347 and I328, its efficacy is enhanced, with pIC50 values of 5.97 and 5.55, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPCR modulator-1 Related Antibodies
Molecular Weight

515.53

Formula

C26H28F3N5O3
CAS No.
SMILES

O=C(O)CCNC(C1=CC=C([C@@H](C2CC(C)(C)C2)NC3=CC=C(N4C=C(C(F)(F)F)N=C4)N=C3)C=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPCR modulator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPCR modulator-11407592-99-7GPCR modulator1GPCR modulator 1GCGRGlucagon ReceptorAllosterictype 2 diabetesInhibitorinhibitorinhibit

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GPCR modulator-1
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