1. Signaling Pathways
  2. GPCR/G Protein
  3. GCGR
  4. GCGR Inhibitor

GCGR Inhibitor

GCGR Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-10930
    UNC0321
    Inhibitor 99.80%
    UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications.
  • HY-P0150
    Glucagon (19-29), human
    Inhibitor 98.15%
    Glucagon (19-29), human is a potent and efficient inhibitor of insulin secretion.
  • HY-50675
    GRA Ex-25
    Inhibitor 98.59%
    GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.
  • HY-P99357
    Crotedumab
    Inhibitor
    Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes.
  • HY-P990013
    Gulgafafusp alfa
    Inhibitor
    Gulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R.