1452387-69-7
1452387-69-7
Chemical Structure
Crotedumab
Synonym(s): REGN1193; Anti-GCGR Reference Antibody (crotedumab)
- CAS No.: 1452387-69-7
- Formula:N/A
- Molecular Weight:(146.82 kDa)
SMILES: [Crotedumab]
Biological Activity: Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes[1][2].
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Crotedumab | 99.22% | Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes. | ||||||||||||||||||||
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References
- [1]. Kostic A, et, al. A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers. Diabetes Obes Metab. 2018 Feb;20(2):283-291. [Content Brief]
- [2]. Okamot H, et, al. Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys. Endocrinology. 2015 Aug;156(8):2781-94. [Content Brief]
Keywords
