GCGR Antagonist

GCGR Antagonists (40):

Cat. No.	Product Name	Effect	Purity

HY-177156

Glucagon receptor antagonist-8	Antagonist
Glucagon receptor antagonist-8 (Compound 1) is a human glucagon receptor and p38 mitogen-activated protein (MAP) kinase antagonist, with IC₅₀s of 0.27 μM and 0.16 μM, respectively.

HY-50663

MK 0893	Antagonist	99.83%
MK 0893 is a potent and selective glucagon receptor antagonist with an IC₅₀ of 6.6 nM.

HY-P1141

GLP-1(9-36)amide	Antagonist	99.69%
GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor.

HY-101116

GLP-1R Antagonist 1	Antagonist	99.67%
GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC₅₀ of 650 nM.

HY-19904

Adomeglivant	Antagonist	99.63%
Adomeglivant (LY2409021) is a potent, selective glucagon receptor (GluR) allosteric antagonist. Adomeglivant is widely used in the research for type 2 diabetes mellitus.

HY-P1023

VIP(6-28)(human, rat, porcine, bovine)	Antagonist	98.09%
VIP(6-28)(human, rat, porcine, bovine) is an effective antagonist of the actions of exogenous vasoactive intestinal peptide (VIP) on cAMP.

HY-12525

LGD-6972	Antagonist	98.0%
LGD-6972 is a selective and orally active glucagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

HY-P99383

Volagidemab	Antagonist	≥99.0%
Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D).

HY-19947

PF-06291874	Antagonist	99.31%
PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM).

HY-103547

L-168049	Antagonist	99.94%
L-168049 is a potent, selective, orally active and non-competitive glucagon receptor antagonist with IC₅₀s of 3.7 nM, 63 nM, and 60 nM for human, murine, and canine glucagon receptors, respectively.

HY-P1143A

[Des-His1,Glu9]-Glucagon amide TFA	Antagonist	98.36%
[Des-His1,Glu9]-Glucagon amide TFA is a potent and peptide antagonist of the glucagon receptor, with a pA₂ of 7.2. [Des-His1,Glu9]-Glucagon amide TFA is potentially useful in the study of the pathogenesis of diabetes.

HY-P1141A

GLP-1(9-36)amide TFA	Antagonist	98.61%
GLP-1(9-36)amide TFA is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor.

HY-50159

Glucagon receptor antagonist-3	Antagonist	99.78%
Glucagon receptor antagonist-3 is a highly potent glucagon receptor antagonist.

HY-148844

GCGR antagonist 2	Antagonist	98.17%
GCGR antagonist 2, a Furan-2-carbohydrazide, is an orally active glucagon receptor antagonist. GCGR antagonist 2 binds to hGluR with an K_d value of 2.3 nM, and inhibits rat receptor with an IC₅₀ value of 0.43 nM. GCGR antagonist 2 inhibits glucagon-stimulated glycogenolysis.

HY-116854

NNC 92-1687	Antagonist	98.74%
NNC 92-1687 is a non-peptide competitive human glucagon receptor antagonist (IC₅₀=20 μM; K_i=9.1 μM). NNC 92-1687 can be used in the research of type 2 diabetes.

HY-50158

Glucagon receptor antagonist-2	Antagonist	99.23%
Glucagon receptor antagonist-2 is a highly potent glucagon receptor antagonist.

HY-145632A

Pemvidutide TFA	Antagonist	98.07%
Pemvidutide (ALT-801) TFA is a GLP-1R/GCGR dual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide TFA can be used in non-alcoholic steatohepatitis (NASH) and obesity research.

HY-P2497

Exendin (5-39)	Antagonist	99.43%
Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.

HY-P1143

[Des-His1,Glu9]-Glucagon amide	Antagonist	99.32%
[Des-His1,Glu9]-Glucagon amide is a potent and peptide antagonist of the glucagon receptor, with a pA₂ of 7.2. [Des-His1,Glu9]-Glucagon amide is potentially useful in the study of the pathogenesis of diabetes.

HY-119739

Skyrin	Antagonist
Skyrin is an anthraquinone compound that can be isolated from almond fruit. Skyrin is a receptor-selective glucagon antagonist. Skyrin can inhibit the growth of tumor cells.

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