1. GPCR/G Protein
  2. Glucagon Receptor
  3. Exendin (5-39)

Exendin (5-39) 

Cat. No.: HY-P2497
Handling Instructions

Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Exendin (5-39) Chemical Structure

Exendin (5-39) Chemical Structure

CAS No. : 196109-27-0

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Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1].

IC50 & Target

IC50: GLP-1 receptor[1]

In Vivo

Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (3 weeks old and 18 days pregnant)[1]
Dosage: 0.3 μg
Administration: Intracerebroventricular injection; 0.3 μg; once daily; 1-week
Result: Inhibited GLT-1 protein levels and inhibited long-term depression in rats.
Molecular Weight








Sequence Shortening



Room temperature in continental US; may vary elsewhere.


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Exendin (5-39)Glucagon ReceptorGCGRGLP-1 receptorimpairmentdepressiondentate gyrusInhibitorinhibitorinhibit

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