1. GPCR/G Protein
  2. GCGR
  3. PF-06291874

PF-06291874 (Synonyms: Glucagon receptor antagonists-4)

Cat. No.: HY-19947 Purity: 99.49%
Handling Instructions

PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM).

For research use only. We do not sell to patients.

PF-06291874 Chemical Structure

PF-06291874 Chemical Structure

CAS No. : 1393124-08-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 321 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 321 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 130 In-stock
Estimated Time of Arrival: December 31
5 mg USD 290 In-stock
Estimated Time of Arrival: December 31
10 mg USD 410 In-stock
Estimated Time of Arrival: December 31
25 mg USD 920 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM)[1][2].

In Vivo

PF-06291874 exposure is approximately dose-proportional with a half-life of ∼19.7-22.7 h. PF-06291874 has a fast on and off rate. PF-06291874 is highly bound to human plasma protein, with a mean free fraction of ∼0.55%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

503.51

Formula

C26H28F3N3O4

CAS No.
SMILES

CCC[[email protected]](OC1=CC(C)=C(N2C=C(C(F)(F)F)C=N2)C(C)=C1)C3=CC=C(C(NCCC(O)=O)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9861 mL 9.9303 mL 19.8606 mL
5 mM 0.3972 mL 1.9861 mL 3.9721 mL
10 mM 0.1986 mL 0.9930 mL 1.9861 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
PF-06291874
Cat. No.:
HY-19947
Quantity:
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