1. GPCR/G Protein
  2. Glucagon Receptor
  3. PF-06291874

PF-06291874 (Synonyms: Glucagon receptor antagonists-4)

Cat. No.: HY-19947 Purity: 99.70%
Handling Instructions

PF-06291874 (Glucagon receptor antagonists-4) is a highly potent and orally active glucagon receptor antagonist. It displays low in vivo clearance in both rats and dogs.

For research use only. We do not sell to patients.

PF-06291874 Chemical Structure

PF-06291874 Chemical Structure

CAS No. : 1393124-08-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 465 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

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Description

PF-06291874 (Glucagon receptor antagonists-4) is a highly potent and orally active glucagon receptor antagonist. It displays low in vivo clearance in both rats and dogs.

Clinical Trial
Molecular Weight

503.51

Formula

C₂₆H₂₈F₃N₃O₄

CAS No.

1393124-08-7

SMILES

CCC[[email protected]](OC1=CC(C)=C(N2C=C(C(F)(F)F)C=N2)C(C)=C1)C3=CC=C(C(NCCC(O)=O)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (59.58 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9861 mL 9.9303 mL 19.8606 mL
5 mM 0.3972 mL 1.9861 mL 3.9721 mL
10 mM 0.1986 mL 0.9930 mL 1.9861 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.70%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PF-06291874Glucagon receptor antagonists-4PF06291874PF 06291874Glucagon receptor antagonists4Glucagon receptor antagonists 4Glucagon ReceptorGCGRglucagonclearanceoralbioavailabilityInhibitorinhibitorinhibit

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Product name:
PF-06291874
Cat. No.:
HY-19947
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