1. GPCR/G Protein
  2. Glucagon Receptor
  3. LGD-6972

LGD-6972 

Cat. No.: HY-12525 Purity: ≥98.0%
Handling Instructions

LGD-6972 is a selective and orally active glucagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

For research use only. We do not sell to patients.

LGD-6972 Chemical Structure

LGD-6972 Chemical Structure

CAS No. : 1207989-09-0

Size Price Stock Quantity
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2220 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

LGD-6972 is a selective and orally active glucagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research[1].

In Vitro

In vitro, LGD-6972 binds competitively to glucagon receptor (GCGR) with high affinity and selectivity, suppressing both cAMP and glucose production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, LGD-6972 reduces acute glucagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting glucagon receptor signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

702.90

Formula

C₄₃H₄₆N₂O₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (44.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4227 mL 7.1134 mL 14.2268 mL
5 mM 0.2845 mL 1.4227 mL 2.8454 mL
10 mM 0.1423 mL 0.7113 mL 1.4227 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
LGD-6972
Cat. No.:
HY-12525
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