1. GPCR/G Protein
  2. Glucagon Receptor

LGD-6972 

Cat. No.: HY-12525 Purity: >98.0%
Handling Instructions

LGD-6972 is a glucagon receptor antagonist.

For research use only. We do not sell to patients.

LGD-6972 Chemical Structure

LGD-6972 Chemical Structure

CAS No. : 1207989-09-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 649 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 2220 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

LGD-6972 is a glucagon receptor antagonist.

In Vivo

LGD-6972 has linear plasma pharmacokinetics consistent with once daily dosing that is comparable in healthy and T2DM subjects. Dose-dependent decreases in fasting plasma glucose are observed in all groups with a maximum of 3.15 mM (56.8 mg/dL) on day 14 in T2DM subjects. LGD-6972 also reduces plasma glucose in the postprandial state. Dose-dependent increases in fasting plasma glucagon are observed, but glucagon levels decrease and insulin levels increase after an oral glucose load in T2DM subjects. LGD-6972 is well tolerated at the doses tested without dose-related or clinically meaningful changes in clinical laboratory parameters. No subject experiences hypoglycaemia[1].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.4227 mL 7.1134 mL 14.2268 mL
5 mM 0.2845 mL 1.4227 mL 2.8454 mL
10 mM 0.1423 mL 0.7113 mL 1.4227 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

702.9

Formula

C₄₃H₄₆N₂O₅S

CAS No.

1207989-09-0

SMILES

O=C(NCCS(=O)(O)=O)C1=CC=C(C[[email protected]](C2=CC=C(C3=CC=C(C(C)(C)C)C=C3)C=C2)C(NC4=CC=C(C5=C(C)C=C(C)C=C5C)C=C4)=O)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
LGD-6972
Cat. No.:
HY-12525
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