2. GPCR/G Protein
  3. GCGR
  4. Des His1, Glu8 Exendin-4

Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist. Des His1, Glu8 Exendin-4 improves glucose homeostasis by regulating both insulin secretion and glucose production. Des His1, Glu8 Exendin-4 can be used for the research of type 2 diabetic and gastrointestinal.

For research use only. We do not sell to patients.

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Des His1, Glu8 Exendin-4 Chemical Structure

Des His1, Glu8 Exendin-4 Chemical Structure

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Des His1, Glu8 Exendin-4 Related Antibodies

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Description

Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist. Des His1, Glu8 Exendin-4 improves glucose homeostasis by regulating both insulin secretion and glucose production. Des His1, Glu8 Exendin-4 can be used for the research of type 2 diabetic and gastrointestinal[1].

In Vivo

Des His1, Glu8 Exendin-4 (dH-EX) (i3vt injection; 50 μg, 2 μL/15 s) improves glucose homeostasis by regulating both insulin secretion and glucose production[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 50 μg, 2 μl/15 s
Administration: i3vt injection
Result: Showed hyperglycemic for the first 45 min after the intraperitoneal glucose load.
Significantly increased insulin levels and insulin area under the curve (AUC) during the IVGTT.
Molecular Weight

4063.46

Formula

C179H277N47O59S
Sequence Shortening

GEGTFTSELSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Des His1, Glu8 Exendin-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Des His1, Glu8 Exendin-4GCGRGlucagon Receptorglucagon-like peptide-1 receptor (GLP-1-R)glucose homeostasisinsulinglucosetype 2 diabeticgastrointestinalInhibitorinhibitorinhibit

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