1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. L-Gulono-1,4-lactone

L-Gulono-1,4-lactone  (Synonyms: L-Gulonolactone)

Cat. No.: HY-W016628 Purity: ≥97.0%
COA Handling Instructions

L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

For research use only. We do not sell to patients.

L-Gulono-1,4-lactone Chemical Structure

L-Gulono-1,4-lactone Chemical Structure

CAS No. : 1128-23-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
500 mg USD 50 In-stock
1 g USD 60 In-stock
5 g   Get quote  
10 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

178.14

Formula

C6H10O6

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1O[C@H]([C@@H](O)CO)[C@H](O)[C@@H]1O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (280.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6136 mL 28.0678 mL 56.1356 mL
5 mM 1.1227 mL 5.6136 mL 11.2271 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.70%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6136 mL 28.0678 mL 56.1356 mL 140.3391 mL
5 mM 1.1227 mL 5.6136 mL 11.2271 mL 28.0678 mL
10 mM 0.5614 mL 2.8068 mL 5.6136 mL 14.0339 mL
15 mM 0.3742 mL 1.8712 mL 3.7424 mL 9.3559 mL
20 mM 0.2807 mL 1.4034 mL 2.8068 mL 7.0170 mL
25 mM 0.2245 mL 1.1227 mL 2.2454 mL 5.6136 mL
30 mM 0.1871 mL 0.9356 mL 1.8712 mL 4.6780 mL
40 mM 0.1403 mL 0.7017 mL 1.4034 mL 3.5085 mL
50 mM 0.1123 mL 0.5614 mL 1.1227 mL 2.8068 mL
60 mM 0.0936 mL 0.4678 mL 0.9356 mL 2.3390 mL
80 mM 0.0702 mL 0.3508 mL 0.7017 mL 1.7542 mL
100 mM 0.0561 mL 0.2807 mL 0.5614 mL 1.4034 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Gulono-1,4-lactone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
L-Gulono-1,4-lactone
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