2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. β-Estradiol 17-acetate

β-Estradiol 17-acetate  (Synonyms: 1,3,5(10)-Estratriene-3,17β-diol 17-acetate)

Cat. No.: HY-B0708 Purity: 99.88%
COA
SDS
Handling Instructions Technical Support

β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice.

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β-Estradiol 17-acetate

β-Estradiol 17-acetate 화학구조

CAS No. : 1743-60-8

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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고객리뷰

Based on 1 publication(s) in Google Scholar

β-Estradiol 17-acetate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE β-Estradiol 17-acetate

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice[1][2].

In Vitro

β-Estradiol 17-acetate (10 nM; 22 d) potently enhances the adhesion and proliferation capacities of hBMEC derived from postmenopausal female patients, and significantly increases the cell density of hBMEC derived from male patients[1].
β-Estradiol 17-acetate (10 nM; 33 d) maintains the viability and sustained proliferative capacity of hBMEC derived from postmenopausal female patients, whereas withdrawal of this hormone causes irreversible loss of cell adhesion and proliferative capacity[1].
β-Estradiol 17-acetate (10 nM; 32 d) restores the viability, adhesion and proliferation capacities of cryopreserved-thawed GM-derived hBMECs, and the adverse effects caused by hormone withdrawal are fully reversed upon re-administration of this substance[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Estradiol 17-acetate Related Antibodies
분자량

314.42

화학식

C20H26O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1([C@H]2OC(C)=O)[C@](CC2)([H])[C@@](CCC3=C4C=CC(O)=C3)([H])[C@]4([H])CC1
Structure Classification
Initial Source

the skin of various animal models

선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
용액&용해도
In Vitro: 

DMSO : 37.5 mg/mL (119.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1805 mL 15.9023 mL 31.8046 mL
5 mM 0.6361 mL 3.1805 mL 6.3609 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.88 mg/mL (5.98 mM); Suspended solution

    This protocol yields a suspended solution of ≥ 1.88 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (18.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.88 mg/mL (5.98 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.88 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (18.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.93%

SDS (396 KB)

COA (250 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1805 mL 15.9023 mL 31.8046 mL 79.5115 mL
5 mM 0.6361 mL 3.1805 mL 6.3609 mL 15.9023 mL
10 mM 0.3180 mL 1.5902 mL 3.1805 mL 7.9511 mL
15 mM 0.2120 mL 1.0602 mL 2.1203 mL 5.3008 mL
20 mM 0.1590 mL 0.7951 mL 1.5902 mL 3.9756 mL
25 mM 0.1272 mL 0.6361 mL 1.2722 mL 3.1805 mL
30 mM 0.1060 mL 0.5301 mL 1.0602 mL 2.6504 mL
40 mM 0.0795 mL 0.3976 mL 0.7951 mL 1.9878 mL
50 mM 0.0636 mL 0.3180 mL 0.6361 mL 1.5902 mL
60 mM 0.0530 mL 0.2650 mL 0.5301 mL 1.3252 mL
80 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9939 mL
100 mM 0.0318 mL 0.1590 mL 0.3180 mL 0.7951 mL
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β-Estradiol 17-acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Estradiol 17-acetate1743-60-81,3,5(10)-Estratriene-3,17β-diol 17-acetateEstrogen Receptor/ERRWM-derived hBMECsrathairless mousepostmenopausal female patientshuman cadaver skinhuman brain microvascular endothelial cellsmale patientsepidermal metabolic activityGM-derived hBMECshairless dogInhibitorinhibitorinhibit

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상품명:
β-Estradiol 17-acetate
Cat. No.:
HY-B0708
수량:
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