2. Immunology/Inflammation Apoptosis
  3. NO Synthase Apoptosis
  4. Aminoguanidine

Aminoguanidine  (Synonyms: Pimagedine; GER-11free base ; Aminoguanidinium)

Art. -Nr.: HY-B1041A
Handling Instructions Technical Support

Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research.

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CAS. Nr. : 79-17-4

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Other In-stock Forms of Aminoguanidine:

Aminoguanidine Related Antibodies

Top Publications Citing Use of Products

    Aminoguanidine purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2025 Oct 21;59(41):21898-21909.  [Abstract]

    Western blot analysis of intracellular levels of the MG-H1 following 24-hour treatment with: 0.5% DMSO (control), 25 μM BPS, 50 μM BPS, 400 μM aminoguanidine + 25 μM BPS, and 400 μM aminoguanidine hydrochloride + 50 μM BPS.

    Aminoguanidine purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2024 Dec:197:107046.  [Abstract]

    BMDMs pretreated with degarelix (1 μM), aminoguanidine hydrochloride (AGHS, 100 μM), BafA1 (100 nM), NAC (5 mM), Z-VAD (20 μM), or 3-MA (5 mM) were infected with H37Rv (MOI = 2). At different time points after infection, bacterial survival was calculated by dividing the CFU at 24 h by the CFU at 3 h.

    Aminoguanidine purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2022 May 17;151:113109.  [Abstract]

    Immunofluorescence analysis showed that the expression of Gli1 protein differed between the high glucose group and the high glucose plus Aminoguanidine (Ami, 500 μM, 24 h) group in organotypic cultured mouse MGs.

    Aminoguanidine purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Dec;120:109527.  [Abstract]

    Treatment with aminoguanidine hydrochloride (AG, 100 mg/kg/d, dissolved in drinking water for 10 weeks), ALA , or PDTC (150 mg/kg/d, dissolved in drinking water for 10 weeks) significantly reduced the RAGE and 3‑NT levels in ZDF rats.

    Aminoguanidine purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Dec;120:109527.  [Abstract]

    The protein expression of the NADPH oxidase subunits NOX2 and p22phox was significantly increased in the ZDF rats, while treatment with aminoguanidine hydrochloride (AG, 100 mg/kg/d, dissolved in drinking water for 10 weeks) or PDTC (150 mg/kg/d, dissolved in drinking water for 10 weeks) specifically reduced the NOX2 and p22phox levels in the ZDF rats.

    Alle NO Synthase Isoform-spezifische Produkte anzeigen:

    Alle Isoformen anzeigen
    nNOS iNOS eNOS

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    Beschreibung

    Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research[1][2][3][4].

    Cellular Effect
    Cell Line Type Value Description References
    DLD-1 IC50
    4.5 3
    Compound: 4
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
    		[PMID: 11327580]
    DLD-1 IC50
    > 1000 3
    Compound: 4
    Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
    Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
    		[PMID: 12620067]
    DLD-1 IC50
    1100 2
    Compound: 4
    Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells
    Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells
    		[PMID: 11327580]
    DLD-1 IC50
    >1 2
    Compound: 4
    Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
    Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
    		[PMID: 12620067]
    DLD-1 IC50
    4.5 3
    Compound: 4
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
    		[PMID: 11327580]
    DLD-1 IC50
    1100 2
    Compound: 4
    Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells
    Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells
    		[PMID: 11327580]
    DLD-1 IC50
    4.5 3
    Compound: 4
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
    		[PMID: 11327580]
    DLD-1 IC50
    54 3
    Compound: 1
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
    		10.1016/0960-894X(95)00273-V
    DLD-1 IC50
    54 3
    Compound: 1
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
    		10.1016/0960-894X(95)00273-V
    HUVEC IC50
    72 3
    Compound: 4
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
    		[PMID: 11327580]
    DLD-1 IC50
    54 3
    Compound: 1
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
    		10.1016/0960-894X(95)00273-V
    DLD-1 IC50
    > 1000 3
    Compound: 4
    Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
    Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
    		[PMID: 12620067]
    J774 IC50
    9 3
    Compound: 1
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
    		10.1016/0960-894X(95)00273-V
    HUVEC IC50
    72 3
    Compound: 4
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
    		[PMID: 11327580]
    J774 IC50
    9 3
    Compound: 1
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
    		10.1016/0960-894X(95)00273-V
    RAW264.7 CC50
    > 100 3
    Compound: Aminoguanidine
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
    		[PMID: 22148193]
    RAW264.7 CC50
    >100 3
    Compound: Aminoguanidine
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
    		[PMID: 22148193]
    RAW264.7 IC50
    0.021 2
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    		[PMID: 18986199]
    RAW264.7 IC50
    7.9 3
    Compound: Aminoguanidine
    Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
    Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
    		[PMID: 21894898]
    RAW264.7 IC50
    0.05 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
    		[PMID: 20192236]
    RAW264.7 IC50
    11.91 3
    Compound: AG
    Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
    Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
    		[PMID: 26280922]
    RAW264.7 IC50
    0.2 3
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
    		[PMID: 21924800]
    RAW264.7 IC50
    18.4 3
    Compound: Aminoguanidine
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
    		[PMID: 27634197]
    RAW264.7 IC50
    0.23 3
    Compound: AG
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    		[PMID: 25176187]
    RAW264.7 IC50
    24.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production
    		[PMID: 37778427]
    RAW264.7 IC50
    1.8 3
    Compound: Aminoguanidine
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 33454546]
    RAW264.7 IC50
    0.05 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
    		[PMID: 20192236]
    RAW264.7 IC50
    11.91 3
    Compound: AG
    Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
    Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
    		[PMID: 26280922]
    RAW264.7 IC50
    16.3 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
    		[PMID: 11809076]
    RAW264.7 IC50
    16.6 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 24035341]
    RAW264.7 IC50
    8.68 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
    		[PMID: 24974350]
    RAW264.7 IC50
    16.6 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 24035341]
    HUVEC IC50
    72 3
    Compound: 4
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
    Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
    		[PMID: 11327580]
    J774 IC50
    9 3
    Compound: 1
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
    Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
    		10.1016/0960-894X(95)00273-V
    RAW264.7 IC50
    7.29 3
    Compound: Aminoguanidine
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
    		[PMID: 25703295]
    RAW264.7 IC50
    16.6 3
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 23743282]
    RAW264.7 IC50
    16.3 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
    		[PMID: 11809076]
    RAW264.7 IC50
    16.9 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    		[PMID: 24813739]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
    Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
    		[PMID: 29280630]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 22079762]
    RAW264.7 IC50
    3.4 6
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    		[PMID: 19435338]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
    Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
    		[PMID: 29280630]
    RAW264.7 IC50
    0.021 92
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    		[PMID: 18986199]
    RAW264.7 IC50
    18.4 3
    Compound: Aminoguanidine
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
    		[PMID: 27634197]
    RAW264.7 IC50
    16.6 3
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 23743282]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
    		[PMID: 27246615]
    RAW264.7 IC50
    22.6 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 22325804]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 26702644]
    RAW264.7 CC50
    > 100 3
    Compound: Aminoguanidine
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
    		[PMID: 22148193]
    RAW264.7 IC50
    22.3 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
    		[PMID: 24597849]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 25592708]
    RAW264.7 IC50
    43.3 3
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
    		[PMID: 24996142]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 33476145]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    		[PMID: 20483604]
    RAW264.7 IC50
    18.7 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
    		[PMID: 23454014]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 25592708]
    RAW264.7 IC50
    19.9 3
    Compound: Aminoguanidine
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 31860303]
    RAW264.7 IC50
    0.021 2
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    		[PMID: 18986199]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 22079762]
    RAW264.7 IC50
    2.7 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
    		[PMID: 20515062]
    RAW264.7 IC50
    20.6 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
    		[PMID: 26073007]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
    		[PMID: 27246615]
    RAW264.7 IC50
    0.05 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
    		[PMID: 20192236]
    RAW264.7 IC50
    0.2 3
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
    		[PMID: 21924800]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 33476145]
    RAW264.7 IC50
    20.6 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
    		[PMID: 26331882]
    RAW264.7 IC50
    0.23 3
    Compound: AG
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    		[PMID: 25176187]
    RAW264.7 IC50
    0.2 3
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
    		[PMID: 21924800]
    RAW264.7 IC50
    20.7 3
    Compound: Aminoguanidine
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    		[PMID: 33667099]
    RAW264.7 IC50
    3.3 6
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
    		[PMID: 20022253]
    RAW264.7 IC50
    21.4 3
    Compound: aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    		[PMID: 24963714]
    RAW264.7 IC50
    1.8 3
    Compound: Aminoguanidine
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 33454546]
    RAW264.7 IC50
    27.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production
    		[PMID: 22066578]
    RAW264.7 IC50
    21.7 3
    Compound: Aminoguanidine
    Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
    Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
    		[PMID: 31244142]
    RAW264.7 IC50
    11.91 3
    Compound: AG
    Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
    Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
    		[PMID: 26280922]
    RAW264.7 IC50
    16.3 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
    		[PMID: 11809076]
    RAW264.7 IC50
    20.6 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
    		[PMID: 26073007]
    RAW264.7 IC50
    22.3 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
    		[PMID: 24597849]
    RAW264.7 IC50
    16.6 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 24035341]
    RAW264.7 IC50
    24.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
    		[PMID: 27976895]
    RAW264.7 IC50
    22.6 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 22325804]
    RAW264.7 IC50
    4.6 3
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
    		[PMID: 21090796]
    RAW264.7 IC50
    16.6 3
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 23743282]
    RAW264.7 IC50
    24.2 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    		[PMID: 27865705]
    RAW264.7 IC50
    16.9 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    		[PMID: 24813739]
    RAW264.7 IC50
    6.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
    		[PMID: 22691179]
    RAW264.7 IC50
    24.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
    		[PMID: 27976895]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    		[PMID: 20483604]
    RAW264.7 IC50
    24.2 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    		[PMID: 27865705]
    RAW264.7 IC50
    25.5 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
    		[PMID: 31642320]
    RAW264.7 IC50
    26.55 3
    Compound: Aminoguanidine
    Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
    Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
    		[PMID: 21846089]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 22079762]
    RAW264.7 IC50
    26.55 3
    Compound: Aminoguanidine
    Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
    Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
    		[PMID: 21846089]
    RAW264.7 IC50
    28.47 3
    Compound: Aminoguanidine
    Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
    Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
    		[PMID: 22148193]
    RAW264.7 IC50
    17.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
    Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
    		[PMID: 29280630]
    RAW264.7 IC50
    28 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
    		[PMID: 19113968]
    RAW264.7 IC50
    21.7 3
    Compound: Aminoguanidine
    Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
    Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
    		[PMID: 31244142]
    RAW264.7 IC50
    28.47 3
    Compound: Aminoguanidine
    Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
    Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
    		[PMID: 22148193]
    RAW264.7 IC50
    18.4 3
    Compound: Aminoguanidine
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
    		[PMID: 27634197]
    RAW264.7 IC50
    20.7 3
    Compound: Aminoguanidine
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    		[PMID: 33667099]
    RAW264.7 IC50
    18.7 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
    		[PMID: 23454014]
    RAW264.7 IC50
    32.17 3
    Compound: aminoguanidine
    Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
    Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
    		[PMID: 17338565]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 26702644]
    RAW264.7 IC50
    32.2 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
    		[PMID: 21273070]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 25592708]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 26702644]
    RAW264.7 IC50
    4.06 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    		[PMID: 14510600]
    RAW264.7 IC50
    20.6 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
    		[PMID: 26331882]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
    		[PMID: 27246615]
    RAW264.7 IC50
    32.2 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation
    		[PMID: 18491868]
    RAW264.7 IC50
    4.6 3
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
    		[PMID: 21090796]
    RAW264.7 IC50
    28 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
    		[PMID: 19113968]
    RAW264.7 IC50
    18.7 3
    Compound: Aminoguanidine
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 33476145]
    RAW264.7 IC50
    43.3 3
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
    		[PMID: 24996142]
    RAW264.7 IC50
    19.9 3
    Compound: Aminoguanidine
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 31860303]
    RAW264.7 IC50
    6.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
    		[PMID: 22691179]
    RAW264.7 IC50
    16.9 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    		[PMID: 24813739]
    RAW264.7 IC50
    4.06 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    		[PMID: 14510600]
    RAW264.7 IC50
    2.7 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
    		[PMID: 20515062]
    RAW264.7 IC50
    7.29 3
    Compound: Aminoguanidine
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
    		[PMID: 25703295]
    RAW264.7 IC50
    20.6 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
    		[PMID: 26331882]
    RAW264.7 IC50
    21.4 3
    Compound: aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    		[PMID: 24963714]
    RAW264.7 IC50
    7.9 3
    Compound: Aminoguanidine
    Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
    Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
    		[PMID: 21894898]
    RAW264.7 IC50
    20.6 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
    		[PMID: 26073007]
    RAW264.7 IC50
    8.68 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
    		[PMID: 24974350]
    RAW264.7 IC50
    32.2 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
    		[PMID: 21273070]
    RAW264.7 IC50
    20.7 3
    Compound: Aminoguanidine
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    		[PMID: 33667099]
    RAW264.7 IC50
    25.5 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
    		[PMID: 31642320]
    RAW264.7 IC50
    21.4 3
    Compound: aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    		[PMID: 24963714]
    RAW264.7 IC50
    2.7 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
    		[PMID: 20515062]
    RAW264.7 IC50
    18.7 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
    		[PMID: 23454014]
    RAW264.7 IC50
    21.7 3
    Compound: Aminoguanidine
    Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
    Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
    		[PMID: 31244142]
    RAW264.7 IC50
    22.3 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
    		[PMID: 24597849]
    RAW264.7 IC50
    1.8 3
    Compound: Aminoguanidine
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 33454546]
    RAW264.7 IC50
    22.6 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 22325804]
    RAW264.7 IC50
    19.9 3
    Compound: Aminoguanidine
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 31860303]
    RAW264.7 IC50
    24.2 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    		[PMID: 27865705]
    RAW264.7 IC50
    0.23 3
    Compound: AG
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    		[PMID: 25176187]
    RAW264.7 IC50
    24.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production
    		[PMID: 37778427]
    RAW264.7 IC50
    32.17 3
    Compound: aminoguanidine
    Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
    Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
    		[PMID: 17338565]
    RAW264.7 IC50
    24.7 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
    		[PMID: 27976895]
    RAW264.7 IC50
    25.5 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
    		[PMID: 31642320]
    RAW264.7 IC50
    26.55 3
    Compound: Aminoguanidine
    Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
    Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
    		[PMID: 21846089]
    RAW264.7 IC50
    27.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production
    		[PMID: 22066578]
    RAW264.7 IC50
    28 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
    		[PMID: 19113968]
    RAW264.7 IC50
    28.47 3
    Compound: Aminoguanidine
    Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
    Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
    		[PMID: 22148193]
    RAW264.7 IC50
    3.3 6
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
    		[PMID: 20022253]
    RAW264.7 IC50
    3.4 6
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    		[PMID: 19435338]
    RAW264.7 IC50
    32.17 3
    Compound: aminoguanidine
    Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
    Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
    		[PMID: 17338565]
    RAW264.7 IC50
    32.2 3
    Compound: AG
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation
    		[PMID: 18491868]
    RAW264.7 IC50
    32.2 3
    Compound: Aminoguanidine
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
    		[PMID: 21273070]
    RAW264.7 IC50
    4.06 3
    Compound: AG
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
    		[PMID: 14510600]
    RAW264.7 IC50
    4.6 3
    Compound: aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
    		[PMID: 21090796]
    RAW264.7 IC50
    43.3 3
    Compound: AG
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
    		[PMID: 24996142]
    RAW264.7 IC50
    6.5 3
    Compound: Aminoguanidine
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
    		[PMID: 22691179]
    RAW264.7 IC50
    7.29 3
    Compound: Aminoguanidine
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
    		[PMID: 25703295]
    RAW264.7 IC50
    7.9 3
    Compound: Aminoguanidine
    Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
    Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
    		[PMID: 21894898]
    RAW264.7 IC50
    8.68 3
    Compound: AG
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
    		[PMID: 24974350]
    Klinische Studie
    Molekulargewicht

    74.09

    Formel

    CH6N4
    CAS. Nr.
    SMILES

    N=C(NN)N
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Reinheit & Dokumentation
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    Aminoguanidine Related Classifications

    • Molaritätsrechner

    • Verdünnungsrechner

    Die Formel zur Berechnung von Molaritäten

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

    Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aminoguanidine79-17-4Pimagedine GER-11free base AminoguanidiniumNO SynthaseApoptosisNitric oxide synthasesNOSInhibitorA549AR42J cellinhibitorinhibit

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