Aminoguanidine hemisulfate
Based on 10 publication(s) in Google Scholar
Aminoguanidine (Pimagedine) hemisulfate is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hemisulfate can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hemisulfate has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hemisulfate has antioxidant properties. Aminoguanidine hemisulfate can be used in the research of diabetic nephropathy.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 996-19-0
- Formula: CH6N4.1/2H2O4
- Molecular Weight:123.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Aminoguanidine hemisulfate
More- Nat Microbiol. 2025 Nov;10(11):2949-2965. [Abstract]
- Nat Commun. 2025 Nov 11;16(1):9923. [Abstract]
- Adv Sci (Weinh). 2025 Dec 19:e12424. [Abstract]
- Environ Sci Technol. 2025 Oct 21;59(41):21898-21909. [Abstract]
- Clin Immunol. 2026 Jun:285:110705. [Abstract]
- Skelet Muscle. 2025 Jan 13;15(1):2. [Abstract]
- Microb Pathog. 2024 Dec:197:107046. [Abstract]
- SSRN. 2024 May 22.
- Biomed Pharmacother. 2022 May 17;151:113109. [Abstract]
- Biomed Pharmacother. 2019 Dec:120:109527. [Abstract]
Customer Validation & Images
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WB
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Cell Proliferation/Viability Assay
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IF
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IHC
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WB
Biological Activity
Aminoguanidine (100-1000 μM, 24 h) hemisulfate can reduce DOX-induced DNA damage and apoptosis in A549 cells [1].
Aminoguanidine (100 μM, 30 min) hemisulfate can induce ERK activation in AR42J cells and promote cell proliferation [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549
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Concentration:100-1000 μM
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Incubation Time:24 h
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Result:Showed protective effect on DOX-induced DNA damage and decreased DOX-induced apoptosis.
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Cell Line:AR42J
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Concentration:100 μM
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Incubation Time:24-96 h
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Result:Showed a significant increase in cell proliferation after incubation for 48 h.
Aminoguanidine (200 mg/kg, Single dose intraperitoneal injection) hemisulfate is protective against cyclophosphamide (CP) (HY-17420)-induced oxidative stress and kidney damage in rats[4].br/>
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss albino mice[3]
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Dosage:50 mg/kg
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Administration:Intraperitoneally 30 min before the administration of CCl4
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Result:Inhibited the serum AST level and protected hepatotoxin-induced lipid peroxidation.
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Animal Model:Adult male Wistar rats[4]
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Dosage:200 mg/kg
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Administration:Intraperitoneally 1 hour before the administration of CP and killed 16 hours after CP injection.
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Result:Attenuated CP-induced MDA elevation and prevented CP-induced protein oxidation.
Restored the GSH levels and attenuated CP-induced increase in MPO activity.
Chemical Information
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CAS No. 996-19-0
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Appearance Solid
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Molecular Weight 123.13
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Formula CH6N4.1/2H2O4
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Color White to pink
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SMILES
O=S(O)(O)=O.N=C(NN)N.[1/2]
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Synonyms
Pimagedine hemisulfate; GER-11 hemisulfate; Aminoguanidinium hemisulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (10)
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Journal Impact Factor
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Most Recent
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Nat Microbiol
Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages. [Abstract]2025 Nov;10(11):2949-2965. PMID: 41073667 -
Nat Commun
Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status. [Abstract]2025 Nov 11;16(1):9923. PMID: 41219185 -
Adv Sci (Weinh)
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance. [Abstract]2025 Dec 19:e12424. PMID: 41417635 -
Environ Sci Technol
Revealing Ferroptosis Induction by Bisphenol A and Bisphenol S through Distinct Protein Targets. [Abstract]2025 Oct 21;59(41):21898-21909. PMID: 41068997
Aminoguanidine hemisulfate purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2025 Oct 21;59(41):21898-21909. [Abstract]
Western blot analysis of intracellular levels of the MG-H1 following 24-hour treatment with: 0.5% DMSO (control), 25 μM BPS, 50 μM BPS, 400 μM aminoguanidine + 25 μM BPS, and 400 μM aminoguanidine hydrochloride + 50 μM BPS.
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Clin Immunol
PLK2 facilitates Mycobacterium tuberculosis clearance via p38 MAPK-mediated ROS production. [Abstract]2026 Jun:285:110705. PMID: 41962814 -
Skelet Muscle
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice. [Abstract]2025 Jan 13;15(1):2. PMID: 39806512 -
Microb Pathog
2024 Dec:197:107046. PMID: 39433139
Aminoguanidine hemisulfate purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2024 Dec:197:107046. [Abstract]
BMDMs pretreated with degarelix (1 μM), aminoguanidine hydrochloride (AGHS, 100 μM), BafA1 (100 nM), NAC (5 mM), Z-VAD (20 μM), or 3-MA (5 mM) were infected with H37Rv (MOI = 2). At different time points after infection, bacterial survival was calculated by dividing the CFU at 24 h by the CFU at 3 h.
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Biomed Pharmacother
Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression. [Abstract]2022 May 17;151:113109. PMID: 35594713
Aminoguanidine hemisulfate purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2022 May 17;151:113109. [Abstract]
Immunofluorescence analysis showed that the expression of Gli1 protein differed between the high glucose group and the high glucose plus Aminoguanidine (Ami, 500 μM, 24 h) group in organotypic cultured mouse MGs.
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Biomed Pharmacother
AGEs impair Kv channel-mediated vasodilation of coronary arteries by activating the NF-κB signaling pathway in ZDF rats. [Abstract]2019 Dec:120:109527. PMID: 31629953
Aminoguanidine hemisulfate purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Dec:120:109527. [Abstract]
Treatment with aminoguanidine hydrochloride (AG, 100 mg/kg/d, dissolved in drinking water for 10 weeks), ALA , or PDTC (150 mg/kg/d, dissolved in drinking water for 10 weeks) significantly reduced the RAGE and 3‑NT levels in ZDF rats.
Aminoguanidine hemisulfate purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Dec:120:109527. [Abstract]
The protein expression of the NADPH oxidase subunits NOX2 and p22phox was significantly increased in the ZDF rats, while treatment with aminoguanidine hydrochloride (AG, 100 mg/kg/d, dissolved in drinking water for 10 weeks) or PDTC (150 mg/kg/d, dissolved in drinking water for 10 weeks) specifically reduced the NOX2 and p22phox levels in the ZDF rats.
Solvent & Solubility
H2O : 100 mg/mL (812.15 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394(1-2):129-35. [Content Brief]
[2]. Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47(5):572-580. PMID: 29066484. [Content Brief]
[3]. Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66(3):265-70. [Content Brief]
[4]. Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16(1):8-14. [Content Brief]
[5]. Zou Z, et al. Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression. Biomed Pharmacother. 2022 Jul;151:113109. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 8.1215 mL | 40.6075 mL | 81.2150 mL | 203.0374 mL |
| 5 mM | 1.6243 mL | 8.1215 mL | 16.2430 mL | 40.6075 mL | |
| 10 mM | 0.8121 mL | 4.0607 mL | 8.1215 mL | 20.3037 mL | |
| 15 mM | 0.5414 mL | 2.7072 mL | 5.4143 mL | 13.5358 mL | |
| 20 mM | 0.4061 mL | 2.0304 mL | 4.0607 mL | 10.1519 mL | |
| 25 mM | 0.3249 mL | 1.6243 mL | 3.2486 mL | 8.1215 mL | |
| 30 mM | 0.2707 mL | 1.3536 mL | 2.7072 mL | 6.7679 mL | |
| 40 mM | 0.2030 mL | 1.0152 mL | 2.0304 mL | 5.0759 mL | |
| 50 mM | 0.1624 mL | 0.8121 mL | 1.6243 mL | 4.0607 mL | |
| 60 mM | 0.1354 mL | 0.6768 mL | 1.3536 mL | 3.3840 mL | |
| 80 mM | 0.1015 mL | 0.5076 mL | 1.0152 mL | 2.5380 mL | |
| 100 mM | 0.0812 mL | 0.4061 mL | 0.8121 mL | 2.0304 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Aminoguanidine hemisulfate Related Classifications
HY-W020772 Related Classifications
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