Cat. No.: HY-B1041A

Aminoguanidine

(Synonyms: Pimagedine; GER-11free base ; Aminoguanidinium)

9 Cited Publications

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Based on 9 publication(s) in Google Scholar

Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research.

For research use only. We do not sell to patients.

CAS No.: 79-17-4
Formula: CH₆N₄
Molecular Weight:74.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Aminoguanidine Chemical Structure

CAS No.: 79-17-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Publications (9)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	1100 mM Compound: 4	Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells	[PMID: 11327580]
DLD-1	IC₅₀	4.5 μM Compound: 4	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells	[PMID: 11327580]
DLD-1	IC₅₀	>1000 μM Compound: 4	Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells	[PMID: 12620067]
DLD-1	IC₅₀	54 μM Compound: 1	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells. Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.	10.1016/0960-894X(95)00273-V
HUVEC	IC₅₀	72 μM Compound: 4	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells	[PMID: 11327580]
J774	IC₅₀	9 μM Compound: 1	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells	10.1016/0960-894X(95)00273-V
RAW264.7	IC₅₀	16.3 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay	[PMID: 11809076]
RAW264.7	IC₅₀	4.06 μM Compound: AG	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method	[PMID: 14510600]
RAW264.7	IC₅₀	32.17 μM Compound: aminoguanidine	Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs	[PMID: 17338565]
RAW264.7	IC₅₀	32.2 μM Compound: AG	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation	[PMID: 18491868]
RAW264.7	IC₅₀	0.021 mM Compound: AG	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]
RAW264.7	IC₅₀	0.021 μM/mL Compound: AG	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]
RAW264.7	IC₅₀	28 μM Compound: AG	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay	[PMID: 19113968]
RAW264.7	IC₅₀	3.4 μg/mL Compound: aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production	[PMID: 19435338]
RAW264.7	IC₅₀	3.3 μg/mL Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release	[PMID: 20022253]
RAW264.7	IC₅₀	0.05 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs	[PMID: 20192236]
RAW264.7	IC₅₀	17.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production	[PMID: 20483604]
RAW264.7	IC₅₀	2.7 μM Compound: AG	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	[PMID: 20515062]
RAW264.7	IC₅₀	4.6 μM Compound: aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA	[PMID: 21090796]
RAW264.7	IC₅₀	32.2 μM Compound: Aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs	[PMID: 21273070]
RAW264.7	IC₅₀	26.55 μM Compound: Aminoguanidine	Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 21846089]
RAW264.7	IC₅₀	7.9 μM Compound: Aminoguanidine	Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction	[PMID: 21894898]
RAW264.7	IC₅₀	0.2 μM Compound: AG	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]
RAW264.7	IC₅₀	27.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production	[PMID: 22066578]
RAW264.7	IC₅₀	17.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 22079762]
RAW264.7	CC₅₀	>100 μM Compound: Aminoguanidine	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay	[PMID: 22148193]
RAW264.7	IC₅₀	28.47 μM Compound: Aminoguanidine	Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method	[PMID: 22148193]
RAW264.7	IC₅₀	22.6 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method	[PMID: 22325804]
RAW264.7	IC₅₀	6.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay	[PMID: 22691179]
RAW264.7	IC₅₀	18.7 μM Compound: AG	Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry	[PMID: 23454014]
RAW264.7	IC₅₀	16.6 μM Compound: aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23743282]
RAW264.7	IC₅₀	16.6 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 24035341]
RAW264.7	IC₅₀	22.3 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis	[PMID: 24597849]
RAW264.7	IC₅₀	16.9 μM Compound: Aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method	[PMID: 24813739]
RAW264.7	IC₅₀	21.4 μM Compound: aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay	[PMID: 24963714]
RAW264.7	IC₅₀	8.68 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control	[PMID: 24974350]
RAW264.7	IC₅₀	43.3 μM Compound: AG	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method	[PMID: 24996142]
RAW264.7	IC₅₀	0.23 μM Compound: AG	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method	[PMID: 25176187]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay	[PMID: 25592708]
RAW264.7	IC₅₀	7.29 μM Compound: Aminoguanidine	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis	[PMID: 25703295]
RAW264.7	IC₅₀	20.6 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method	[PMID: 26073007]
RAW264.7	IC₅₀	11.91 μM Compound: AG	Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method	[PMID: 26280922]
RAW264.7	IC₅₀	20.6 μM Compound: AG	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction	[PMID: 26331882]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 26702644]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method	[PMID: 27246615]
RAW264.7	IC₅₀	18.4 μM Compound: Aminoguanidine	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay	[PMID: 27634197]
RAW264.7	IC₅₀	24.2 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis	[PMID: 27865705]
RAW264.7	IC₅₀	24.7 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay	[PMID: 27976895]
RAW264.7	IC₅₀	17.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay	[PMID: 29280630]
RAW264.7	IC₅₀	21.7 μM Compound: Aminoguanidine	Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay	[PMID: 31244142]
RAW264.7	IC₅₀	25.5 μM Compound: Aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay	[PMID: 31642320]
RAW264.7	IC₅₀	19.9 μM Compound: Aminoguanidine	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 31860303]
RAW264.7	IC₅₀	1.8 μM Compound: Aminoguanidine	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 33454546]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 33476145]
RAW264.7	IC₅₀	20.7 μM Compound: Aminoguanidine	Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay	[PMID: 33667099]
RAW264.7	IC₅₀	24.5 μM Compound: Aminoguanidine	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production	[PMID: 37778427]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 79-17-4
Molecular Weight 74.09
Formula CH₆N₄
SMILES

N=C(NN)N
Synonyms

Pimagedine; GER-11free base ; Aminoguanidinium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (9)

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Journal Impact Factor

Nat Microbiol

Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages. [Abstract]

2025 Nov;10(11):2949-2965. PMID: 41073667
Nat Commun

Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status. [Abstract]

2025 Nov 11;16(1):9923. PMID: 41219185
Adv Sci (Weinh)

Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance. [Abstract]

2025 Dec 19:e12424. PMID: 41417635
Environ Sci Technol

Revealing Ferroptosis Induction by Bisphenol A and Bisphenol S through Distinct Protein Targets. [Abstract]

2025 Oct 21;59(41):21898-21909. PMID: 41068997

Aminoguanidine purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2025 Oct 21;59(41):21898-21909. [Abstract]

Western blot analysis of intracellular levels of the MG-H1 following 24-hour treatment with: 0.5% DMSO (control), 25 μM BPS, 50 μM BPS, 400 μM aminoguanidine + 25 μM BPS, and 400 μM aminoguanidine hydrochloride + 50 μM BPS.
Biomed Pharmacother

Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression. [Abstract]

2022 May 17;151:113109. PMID: 35594713

Aminoguanidine purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2022 May 17;151:113109. [Abstract]

Immunofluorescence analysis showed that the expression of Gli1 protein differed between the high glucose group and the high glucose plus Aminoguanidine (Ami, 500 μM, 24 h) group in organotypic cultured mouse MGs.
Biomed Pharmacother

AGEs impair Kv channel-mediated vasodilation of coronary arteries by activating the NF-κB signaling pathway in ZDF rats. [Abstract]

2019 Dec;120:109527. PMID: 31629953

Aminoguanidine purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Dec;120:109527. [Abstract]

Treatment with aminoguanidine hydrochloride (AG, 100 mg/kg/d, dissolved in drinking water for 10 weeks), ALA , or PDTC (150 mg/kg/d, dissolved in drinking water for 10 weeks) significantly reduced the RAGE and 3‑NT levels in ZDF rats.

Aminoguanidine purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Dec;120:109527. [Abstract]

The protein expression of the NADPH oxidase subunits NOX2 and p22phox was significantly increased in the ZDF rats, while treatment with aminoguanidine hydrochloride (AG, 100 mg/kg/d, dissolved in drinking water for 10 weeks) or PDTC (150 mg/kg/d, dissolved in drinking water for 10 weeks) specifically reduced the NOX2 and p22phox levels in the ZDF rats.
Skelet Muscle

Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice. [Abstract]

2025 Jan 13;15(1):2. PMID: 39806512
Microb Pathog

Degarelix limits the survival of mycobacteria and granuloma formation. [Abstract]

2024 Dec:197:107046. PMID: 39433139

Aminoguanidine purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2024 Dec:197:107046. [Abstract]

BMDMs pretreated with degarelix (1 μM), aminoguanidine hydrochloride (AGHS, 100 μM), BafA1 (100 nM), NAC (5 mM), Z-VAD (20 μM), or 3-MA (5 mM) were infected with H37Rv (MOI = 2). At different time points after infection, bacterial survival was calculated by dividing the CFU at 24 h by the CFU at 3 h.
SSRN

2024 May 22.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394(1-2):129-35. [Content Brief]

[2]. Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47(5):572-580. PMID: 29066484. [Content Brief]

[3]. Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66(3):265-70. [Content Brief]

[4]. Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16(1):8-14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Aminoguanidine

9 Cited Publications

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Aminoguanidine

Publications Citing Use of MedChemExpress (MCE) Aminoguanidine

All NO Synthase Isoforms

Biological Activity

Chemical Information

Publications (9)

Purity & Documentation

References

Calculators

Help & FAQs

Aminoguanidine Related Classifications

Cat. No.: HY-B1041A