Terpenoid constituents of Abies chensiensis with potential anti-inflammatory activity

  • J Nat Prod. 2009 Jun;72(6):1065-8. doi: 10.1021/np800790h.
Yong-Li Li  1 ,  Xian-Wen Yang ,  Su-Mei Li ,  Yun-Heng Shen ,  Hua-Wu Zeng ,  Xiao-Hua Liu ,  Jian Tang ,  Wei-Dong Zhang
Affiliations
  • 1. Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
PMID: 19435338 DOI: 10.1021/np800790h
Abstract

Six new Triterpenes (neoabieslactones A-F, 1-6) and 17 known compounds were isolated from the aerial parts of Abies chensiensis. The structures of the new Triterpenes were proposed by 1D and 2D NMR spectroscopy. Compound 1 was confirmed structurally by X-ray crystallography. In a bioassay against LPS-induced NO production in RAW264.7 macrophages, three compounds, neoabieslactone E (5), (12R,13R)-8,12-epoxy-14-labden-13-ol (7), and manool (8), exhibited IC(50) values of 9.1, 1.9, and 9.6 microg/mL, respectively.