Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

  • Bioorg Med Chem Lett. 2010 Jun 15;20(12):3785-7. doi: 10.1016/j.bmcl.2010.04.054.
Ji Sang Hwang  1 ,  Seon A Lee ,  Seong Su Hong ,  Xiang Hua Han ,  Chul Lee ,  Shin Jung Kang ,  Dongho Lee ,  Youngsoo Kim ,  Jin Tae Hong ,  Mi Kyeong Lee ,  Bang Yeon Hwang
Affiliations
  • 1. College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
PMID: 20483604 DOI: 10.1016/j.bmcl.2010.04.054
Abstract

Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC(50) values ranging from 9.6 microM to 35.7 microM.