2-Phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production

  • J Nat Prod. 2014 Jul 25;77(7):1724-8. doi: 10.1021/np400831p.
Qinghao Jin  1 ,  Chul Lee ,  Jin Woo Lee ,  Eung Tae Yeon ,  Dongho Lee ,  Sang Bae Han ,  Jin Tae Hong ,  Youngsoo Kim ,  Mi Kyeong Lee ,  Bang Yeon Hwang
Affiliations
  • 1. College of Pharmacy, Chungbuk National University , Cheongju 361-763, Korea.
PMID: 24963714 DOI: 10.1021/np400831p
Abstract

Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC50 values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.

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