3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency

  • Bioorg Med Chem Lett. 2001 Apr 23;11(8):1023-6. doi: 10.1016/s0960-894x(01)00119-6.
H Beaton  1 ,  P Hamley ,  D J Nicholls ,  A C Tinker ,  A V Wallace
Affiliations
  • 1. Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Loughborough, UK.
PMID: 11327580 DOI: 10.1016/s0960-894x(01)00119-6
Abstract

3-Phenyl-3.4-dihydro-1-isoquinolinamine is a weak inhibitor of iNOS and nNOS. Structural variation of 5a results in inhibitors with a range of potency and selectivity for the NOS Enzymes, including a potent and very selective iNOS Inhibitor 5j.