Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production

  • J Nat Prod. 2019 Nov 22;82(11):3002-3009. doi: 10.1021/acs.jnatprod.9b00520.
Qinghao Jin  1 ,  Jin Woo Lee  1 ,  Jun Gu Kim  1 ,  Dongho Lee  2 ,  Jin Tae Hong  1 ,  Youngsoo Kim  1 ,  Mi Kyeong Lee  1 ,  Bang Yeon Hwang  1
Affiliations
  • 1. College of Pharmacy , Chungbuk National University , Cheongju 28160 , South Korea.
  • 2. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology , Korea University , Seoul 02841 , South Korea.
PMID: 31642320 DOI: 10.1021/acs.jnatprod.9b00520
Abstract

Three biogenetically related ent-sauchinone-type Lignans (1-3), four 8-O-4'-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type Lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 μM, respectively.