Dimeric ent-kaurane diterpenoids from Isodon excisus

  • J Nat Prod. 2011 Nov 28;74(11):2382-7. doi: 10.1021/np200439n.
Seong Su Hong  1 ,  Seon A Lee ,  Chul Lee ,  Xiang Hua Han ,  Sanggil Choe ,  Nahyun Kim ,  Dongho Lee ,  Chong-Kil Lee ,  Youngsoo Kim ,  Jin Tae Hong ,  Mi Kyeong Lee ,  Bang Yeon Hwang
Affiliations
  • 1. College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
PMID: 22066578 DOI: 10.1021/np200439n
Abstract

Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus. The structures and relative configurations of these compounds were determined on the basis of spectroscopic data interpretation. Of these, biexcisusins C-E (3-5) are dimeric ent-kaurane Diterpenoids exhibiting an unprecedented linkage through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1-5 showed no inhibitory effects on the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.