Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

  • Bioorg Med Chem Lett. 2011 Feb 15;21(4):1279-81. doi: 10.1016/j.bmcl.2010.11.095.
Seong Su Hong  1 ,  Seon A Lee ,  Nahyun Kim ,  Ji Sang Hwang ,  Xiang Hua Han ,  Mi Kyeong Lee ,  Jae Kyung Jung ,  Jin Tae Hong ,  Youngsoo Kim ,  Dongho Lee ,  Bang Yeon Hwang
Affiliations
  • 1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
PMID: 21273070 DOI: 10.1016/j.bmcl.2010.11.095
Abstract

A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC(50) value of 10.4 and 3.8 μM, respectively.