2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Monoamine Oxidase DYRK
  4. AnnH31

AnnH31 is a Dyrk1A inhibitor (IC50: 81 nM). AnnH31 also inhibits MAO-A with an IC50 of 3.2 μM. AnnH31 inhibits cell viability of HeLa, PC12 and SH-SY5Y cells.

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AnnH31

AnnH31 Chemische Struktur

CAS. Nr. : 241809-12-1

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AnnH31 Related Antibodies

Top Publications Citing Use of Products

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
MAO-A MAO-B

Alle DYRK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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Beschreibung

AnnH31 is a Dyrk1A inhibitor (IC50: 81 nM). AnnH31 also inhibits MAO-A with an IC50 of 3.2 μM. AnnH31 inhibits cell viability of HeLa, PC12 and SH-SY5Y cells[1].

IC50 & Target

81 nM (Dyrk1A), 3.2 μM (MAO-A)[1]
In Vitro

AnnH31 (1-10 μM; for 3 days) reduces cell viability when used at high concentrations in HeLa, PC12 and SH-SY5Y cells.[1].
AnnH31 (0.33-3 μM; for 18 h) reduces the phosphorylation of SF3B1 and SEPT4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AnnH31 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa, PC12 and SH-SY5Y cells
Concentration: 1 μM, 3 μM, 10 μM
Incubation Time: for 3 days
Result: Reduced cell viability when used at high concentrations.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0.33 μM, 1 μM, 3 μM
Incubation Time: 18 h
Result: Reduced the phosphorylation of SF3B1 and SEPT4.
Molekulargewicht

251.28

Formel

C15H13N3O
CAS. Nr.
Appearance

Solid

Color

Light brown to brown

SMILES

N#CCN1C2=C(C3=C1C=C(C=C3)OC)C=CN=C2C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (497.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9796 mL 19.8981 mL 39.7962 mL
5 mM 0.7959 mL 3.9796 mL 7.9592 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9796 mL 19.8981 mL 39.7962 mL 99.4906 mL
5 mM 0.7959 mL 3.9796 mL 7.9592 mL 19.8981 mL
10 mM 0.3980 mL 1.9898 mL 3.9796 mL 9.9491 mL
15 mM 0.2653 mL 1.3265 mL 2.6531 mL 6.6327 mL
20 mM 0.1990 mL 0.9949 mL 1.9898 mL 4.9745 mL
25 mM 0.1592 mL 0.7959 mL 1.5918 mL 3.9796 mL
30 mM 0.1327 mL 0.6633 mL 1.3265 mL 3.3164 mL
40 mM 0.0995 mL 0.4975 mL 0.9949 mL 2.4873 mL
50 mM 0.0796 mL 0.3980 mL 0.7959 mL 1.9898 mL
60 mM 0.0663 mL 0.3316 mL 0.6633 mL 1.6582 mL
80 mM 0.0497 mL 0.2487 mL 0.4975 mL 1.2436 mL
100 mM 0.0398 mL 0.1990 mL 0.3980 mL 0.9949 mL
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AnnH31 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AnnH31241809-12-1AnnH 31AnnH-31Monoamine OxidaseDYRKMAODual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseDyrk1A inhibitionMAO-A inhibitionInhibitorinhibitorinhibit

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