2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Parasite Reactive Oxygen Species (ROS)
  4. Antiparasitic agent-27

Antiparasitic agent-27 (Compound 2) is a potent antiparasitic agent targeting Leishmania infantum (IC50=3.1 μM). Antiparasitic agent-27 induces G0/G1 cell cycle arrest and reactive oxygen species (ROS) generation to trigger programmed cell death. Antiparasitic agent-27 is promising for research of visceral leishmaniasis (VL).

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Antiparasitic agent-27

Antiparasitic agent-27 Estructura química

No. CAS : 3048504-54-4

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Antiparasitic agent-27 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Descripciòn

Antiparasitic agent-27 (Compound 2) is a potent antiparasitic agent targeting Leishmania infantum (IC50=3.1 μM). Antiparasitic agent-27 induces G0/G1 cell cycle arrest and reactive oxygen species (ROS) generation to trigger programmed cell death. Antiparasitic agent-27 is promising for research of visceral leishmaniasis (VL)[1].

Cellular Effect
Cell Line Type Value Description References
THP-1 CC50
1074 μM
Compound: 12
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by alamarblue staining based analysis
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by alamarblue staining based analysis
[PMID: 37156183]
Peso molecular

284.31

Fòrmula

C15H16N4O2
No. CAS
SMILES

O=C(C1=CC=C(O)C=C1)N2CCN(C3=NC=CN=C3)CC2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Antiparasitic agent-27 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiparasitic agent-273048504-54-4Antiparasitic agent27Antiparasitic agent 27ParasiteReactive Oxygen Species (ROS)antiparasitic agentROSvisceral leishmaniasisInhibitorinhibitorinhibit

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Antiparasitic agent-27
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HY-175364
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