Ardisiacrispin B

製品番号: HY-N8198 純度: 99.94%: Data Sheet SDS COA 取扱説明書
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Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death.

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Ardisiacrispin B 構造式

CAS 番号 : 112766-96-8

容量	価格（税別）	在庫状況	数量
5 mg	$300	在庫あり	Estimated Time of Arrival: December 31
10 mg	$480	在庫あり	Estimated Time of Arrival: December 31
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100 mg		お問い合わせ

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製品説明

Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.6 3 Compound: 10, ardisiacrispin B	Cytotoxicity against human A549 cell line by MTT assay Cytotoxicity against human A549 cell line by MTT assay	[PMID: 17243725]
A549	IC₅₀	3.6 3 Compound: 10, ardisiacrispin B	Cytotoxicity against human A549 cell line by MTT assay Cytotoxicity against human A549 cell line by MTT assay	[PMID: 17243725]
A549	IC₅₀	3.6 3 Compound: 10, ardisiacrispin B	Cytotoxicity against human A549 cell line by MTT assay Cytotoxicity against human A549 cell line by MTT assay	[PMID: 17243725]
Bel-7402	IC₅₀	4.46 2 Compound: 9	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 22940450]
Bel-7402	IC₅₀	4.46 2 Compound: 9	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 22940450]
Bel-7402	IC₅₀	4.46 2 Compound: 9	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 22940450]
HepG2	IC₅₀	1.53 3 Compound: 12	Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HL-60	IC₅₀	22.58 3 Compound: 12	Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HepG2	IC₅₀	1.53 3 Compound: 12	Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HepG2	IC₅₀	20.96 2 Compound: 9	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22940450]
HepG2	IC₅₀	20.96 2 Compound: 9	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22940450]
HL-60	IC₅₀	3.2 3 Compound: 10, ardisiacrispin B	Cytotoxicity against human HL60 cell line by MTT assay Cytotoxicity against human HL60 cell line by MTT assay	[PMID: 17243725]
HL-60	IC₅₀	22.58 3 Compound: 12	Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HL-60	IC₅₀	22.58 3 Compound: 12	Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HepG2	IC₅₀	1.53 3 Compound: 12	Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HL-60	IC₅₀	3.2 3 Compound: 10, ardisiacrispin B	Cytotoxicity against human HL60 cell line by MTT assay Cytotoxicity against human HL60 cell line by MTT assay	[PMID: 17243725]
HL-60	IC₅₀	3.2 3 Compound: 10, ardisiacrispin B	Cytotoxicity against human HL60 cell line by MTT assay Cytotoxicity against human HL60 cell line by MTT assay	[PMID: 17243725]
HepG2	IC₅₀	20.96 2 Compound: 9	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22940450]
KB	IC₅₀	1.6 3 Compound: 12	Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
KB	IC₅₀	1.6 3 Compound: 12	Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
KB	IC₅₀	1.6 3 Compound: 12	Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
L02	IC₅₀	>100 2 Compound: 9	Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay	[PMID: 22940450]
L02	IC₅₀	> 100 2 Compound: 9	Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay	[PMID: 22940450]
L02	IC₅₀	> 100 2 Compound: 9	Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay	[PMID: 22940450]
LNCaP	IC₅₀	9.7 3 Compound: 12	Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
LNCaP	IC₅₀	9.7 3 Compound: 12	Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
LNCaP	IC₅₀	9.7 3 Compound: 12	Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Lu1	IC₅₀	1.41 3 Compound: 12	Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Lu1	IC₅₀	1.41 3 Compound: 12	Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Lu1	IC₅₀	1.41 3 Compound: 12	Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MDA-MB-231	IC₅₀	11.76 3 Compound: 12	Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MDA-MB-231	IC₅₀	11.76 3 Compound: 12	Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MDA-MB-231	IC₅₀	11.76 3 Compound: 12	Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MKN-7	IC₅₀	1.27 3 Compound: 12	Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MKN-7	IC₅₀	1.27 3 Compound: 12	Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MKN-7	IC₅₀	1.27 3 Compound: 12	Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
SW480	IC₅₀	1.24 3 Compound: 12	Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
SW480	IC₅₀	1.24 3 Compound: 12	Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
SW480	IC₅₀	1.24 3 Compound: 12	Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]

分子量

1075.24

分子式

C₅₃H₈₆O₂₂

CAS 番号

112766-96-8

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]3(CC[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@H](CO6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO)C)C)[C@@]%10([H])[C@@]([C@@H](C1)O)(CC[C@@](C)(C%10)C=O)CO3

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (93.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9300 mL	4.6501 mL	9.3002 mL
5 mM	0.1860 mL	0.9300 mL	1.8600 mL
10 mM	0.0930 mL	0.4650 mL	0.9300 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.94%

Select Batch:

データシート (274 KB) SDS (252 KB)

COA (259 KB) HNMR (524 KB) CNMR (1054 KB) RP-HPLC (245 KB) MS (296 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Armelle T Mbaveng, et al. A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Phytomedicine. 2018 Apr 1;43:78-85. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9300 mL	4.6501 mL	9.3002 mL	23.2506 mL
	5 mM	0.1860 mL	0.9300 mL	1.8600 mL	4.6501 mL
	10 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3251 mL
	15 mM	0.0620 mL	0.3100 mL	0.6200 mL	1.5500 mL
	20 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	25 mM	0.0372 mL	0.1860 mL	0.3720 mL	0.9300 mL
	30 mM	0.0310 mL	0.1550 mL	0.3100 mL	0.7750 mL
	40 mM	0.0233 mL	0.1163 mL	0.2325 mL	0.5813 mL
	50 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.4650 mL
	60 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.3875 mL
	80 mM	0.0116 mL	0.0581 mL	0.1163 mL	0.2906 mL