2. Immunology/Inflammation
  3. Interleukin Related
  4. Basiliximab

Basiliximab  (Synonyms: CHI 621)

Art. -Nr.: HY-108852 Reinheit: ≥99.0%
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Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation.

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CAS. Nr. : 179045-86-4

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Basiliximab Related Antibodies

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Beschreibung

Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

IL-2Ra/CD25
In Vitro

Basiliximab specifically inhibits T lymphocyte proliferation by binding to the IL-2Rα[1].
Basiliximab binds only to activated lymphocytes and macrophages/monocytes[3].
Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Basiliximab Related Antibodies
In Vivo

Basiliximab (CHI 621) (0.07 mg/rat; i.v.; once) decreases total placental natural killer cells in reduced uterine perfusion pressure (RUPP) rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Timed-pregnant Sprague Dawley (SD) rats, reduced uterine perfusion pressure (RUPP) rat model of placental ischemia[2]
Dosage: 0.07 mg/rat
Administration: IV infusion, once
Result: Decreased total placental natural killer cells. Had no effect to lower MAP or improve pup weight and placental weight.
Klinische Studie
Gene ID

3559  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

143.56 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Basiliximab]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized IL-2R alpha/CD25 Protein, Human (HEK293, C-His, HY-P70628) can bind Basiliximab. The EC50 for this effect is 35.99 ng/mL.
  • Flow Cytometry analysis of Romas cells labelling IL-2Ra/CD25 (red) with Basiliximab (anti-IL-2Ra/CD25) (HY-P108852). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).
Reinheit & Dokumentation

Purity: ≥99.0%

SDS (251 KB)

COA (232 KB) SDS-PAGE (63 KB) SEC-HPLC (230 KB)

Inhibitory Antibodies User Guide (603 KB)
Verweise
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Basiliximab Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Basiliximab179045-86-4CHI 621CHI621CHI-621Interleukin RelatedILrenal transplantationplacental ischemiapreeclampsiaInhibitorinhibitorinhibit

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