2. GPCR/G Protein
  3. LPL Receptor
  4. CAY10444

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors.

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CAY10444

CAY10444 Estructura química

No. CAS : 298186-80-8

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
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Based on 4 publication(s) in Google Scholar

CAY10444 Related Antibodies

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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Descripciòn

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].

IC50 & Target[1]

S1PR3

 

Cellular Effect
Cell Line Type Value Description References
CHO-K1 IC50
11.6 3
Compound: 6, RH00669
Antagonist activity against human S1P3 receptor assessed as inhibition of S1P-induced intracellular calcium mobilization in CHO-K1 cells
Antagonist activity against human S1P3 receptor assessed as inhibition of S1P-induced intracellular calcium mobilization in CHO-K1 cells
[PMID: 17266196]
CHO-K1 IC50
11.6 3
Compound: 6, RH00669
Antagonist activity against human S1P3 receptor assessed as inhibition of S1P-induced intracellular calcium mobilization in CHO-K1 cells
Antagonist activity against human S1P3 receptor assessed as inhibition of S1P-induced intracellular calcium mobilization in CHO-K1 cells
[PMID: 17266196]
In Vitro

BML-241 inhibits increases in intracellular Ca2+ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAY10444 Related Antibodies
Peso molecular

287.46

Fòrmula

C15H29NO2S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H]1NC(SC1)CCCCCCCCCCC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 10 mg/mL (34.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4787 mL 17.3937 mL 34.7874 mL
5 mM 0.6957 mL 3.4787 mL 6.9575 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 98.0%

SDS (393 KB)

COA (241 KB) HNMR (250 KB) MS (180 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4787 mL 17.3937 mL 34.7874 mL 86.9686 mL
5 mM 0.6957 mL 3.4787 mL 6.9575 mL 17.3937 mL
10 mM 0.3479 mL 1.7394 mL 3.4787 mL 8.6969 mL
15 mM 0.2319 mL 1.1596 mL 2.3192 mL 5.7979 mL
20 mM 0.1739 mL 0.8697 mL 1.7394 mL 4.3484 mL
25 mM 0.1391 mL 0.6957 mL 1.3915 mL 3.4787 mL
30 mM 0.1160 mL 0.5798 mL 1.1596 mL 2.8990 mL
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CAY10444 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY10444298186-80-8BML-241CAY 10444CAY-10444BML241BML 241LPL ReceptorLysophospholipid ReceptorS1P3 antagonistS1P3 receptorsCa2+ concentrationInhibitorinhibitorinhibit

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Nombre del producto:
CAY10444
Cat. No.:
HY-119401
Cantidad:
MCE Japan Authorized Agent:

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