Cefprozil 

Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections^[1][2].

Cefprozil inhibits S. pyogenes, S. pneumoniae, S. agalactiae, S. aureus (methicillin-susceptible), H. influenzae, M. catarrhalis, E. coli with MIC₉₀s of 0.04, 0.23, 0.3, 1.4, 6.7, 4.5, 12.2 mg/L, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefprozil (two doses, injection) exhibits antibacterial activity against E. coli, H. influenzae, K. pneumoniae, P. mirabilis, S. aureus (β-lactamase-negative), S. aureus (β-lactamase-positive), S. pneumoniae, and S. pyogenes in mouse models, with ED₅₀s of 2.0, 3.1, 2.8, 1.5, 0.04, 18, 1.0 and 0.08 mg/kg, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

389.43

C₁₈H₁₉N₃O₅S

92665-29-7

Solid

OC(C(N1[C@@]2([H])[C@H](NC([C@@H](C3=CC=C(O)C=C3)N)=O)C1=O)=C(CS2)/C=C/C)=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. J C Fung-Tom, et al. Antibacterial activities of cefprozil compared with those of 13 oral cephems and 3 macrolides. Antimicrob Agents Chemother. 1995 Feb;39(2):533-8.  [Content Brief]

  [2]. Wiseman LR, et al., Cefprozil. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic potential. Drugs. 1993 Feb;45(2):295-317.  [Content Brief]