2. Apoptosis MAPK/ERK Pathway
  3. Apoptosis p38 MAPK
  4. Chromium picolinate

ピコリン酸クロム  (Synonyms: Chromium picolinate; Chromium (III) picolinate; Cr(Pic)3)

製品番号: HY-125588 純度: 99.76%
COA 取扱説明書 Technical Support

Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes.

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Chromium picolinate

ピコリン酸クロム 構造式

CAS 番号 : 14639-25-9

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
100 mg $50 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Chromium picolinate:

ピコリン酸クロム 関連抗体

Top Publications Citing Use of Products

p38 MAPK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes[1][2][3][4].

体外実験

Chromium picolinate (5-100 μM, 24-72 h) induces lymphocyte apoptosis through ROS and mitochondrial events[1].
Chromium picolinate (100 nM, 24 h) exerts hypoglycemic effects in insulin-resistant 3T3-L1 adipocytes by activating p38 MAPK[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ピコリン酸クロム 関連抗体

Cell Viability Assay[1]

Cell Line: lymphocytes
Concentration: 5,10, 25, 50, 75, 100 μM
Incubation Time: 24-72 h
Result: Inhibited cell viability from concentration of 25 μM.

Western Blot Analysis[1]

Cell Line: lymphocytes
Concentration: 50, 100 μM
Incubation Time: 24 h
Result: Increased the expression of Bax. and cytochrome.
Increased the activity of caspase-3.
体内実験

Chromium picolinate (100 mg/kg/day, orally, once daily for 4 weeks) causes weight gain and improves insulin sensitivity in Goto-Kakizaki diabetic rats[3].
Chromium picolinate (1 mg/kg/day, orally, once a daily for 4 weeks) can reduce the oxidative stress response of hyperglycemia induced by streptozotocin (HY-13753) in diabetic rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Goto-Kakizaki diabetic rats [3]
Dosage: 100 mg/kg
Administration: p.o.
Result: Increased body weight.
The glucose levels were significantly lower in GK-CrP rats compared with GK-control rats.
Animal Model: Streptozotocin-induced diabetic rats[4]
Dosage: 1 mg/kg
Administration: p.o.
Result: Attenuated hyperglycemia and lowered lipid peroxidation in diabetic rats.
Restored the activity of SOD, catalase, GR, antioxidant capacity, ALT and AST.
臨床実験
分子量

418.30

分子式

C18H12CrN3O6
CAS 番号
Appearance

Solid

Color

Pink to red

SMILES

O=C1[O-][Cr+3]([N]2=C(C=CC=C2)C3=O)([O-]3)([N]4=C(C=CC=C4)C5=O)([O-]5)[N]6=C1C=CC=C6
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 7.81 mg/mL (18.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3906 mL 11.9531 mL 23.9063 mL
5 mM 0.4781 mL 2.3906 mL 4.7813 mL
10 mM 0.2391 mL 1.1953 mL 2.3906 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3906 mL 11.9531 mL 23.9063 mL 59.7657 mL
5 mM 0.4781 mL 2.3906 mL 4.7813 mL 11.9531 mL
10 mM 0.2391 mL 1.1953 mL 2.3906 mL 5.9766 mL
15 mM 0.1594 mL 0.7969 mL 1.5938 mL 3.9844 mL
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Chromium picolinate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chromium picolinate14639-25-9Chromium (III) picolinate Cr(Pic)3Apoptosisp38 MAPKActivitorLymphocytes3T3-L1Diabetic ratsInhibitorinhibitorinhibit

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製品名:
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製品番号:
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