2. Others Apoptosis Anti-infection Metabolic Enzyme/Protease
  3. Environmental Pollutants Bacterial Endogenous Metabolite Apoptosis
  4. Citric acid trisodium

くえん酸三ナトリウム  (Synonyms: Citric acid trisodium; Sodium citrate; Trisodium citrate anhydrous)

製品番号: HY-B2201 純度: 98.0%
COA 取扱説明書 Technical Support

Citric acid trisodium (Sodium citrate) is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.

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Citric acid trisodium

くえん酸三ナトリウム 構造式

CAS 番号 : 68-04-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $35 在庫あり
1 g $45 在庫あり
5 g $90 在庫あり
10 g $126 在庫あり
50 g   お問い合わせ  

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Based on 11 publication(s) in Google Scholar

Other Forms of Citric acid trisodium:

くえん酸三ナトリウム 関連抗体

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Human Endogenous Metabolite Microbial Metabolite

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製品説明

Citric acid trisodium (Sodium citrate) is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
>100 μM
Compound: Sodium citrate
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 37360398]
HepG2 IC50
>100 μM
Compound: Sodium citrate
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 37360398]
HGC-27 IC50
>100 μM
Compound: Sodium citrate
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 37360398]
L02 IC50
>100 μM
Compound: Sodium citrate
Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 37360398]
MDA-MB-231 IC50
>100 μM
Compound: Sodium citrate
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 37360398]
SMMC-7721 IC50
>100 μM
Compound: Sodium citrate
Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 37360398]
体外実験

Citric acid (0-12.5 mM; 24 h) trisodium shows antiproliferative activity in a dose dependent manner[3].
Citric acid (12.5 mM; 72 h) trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].
Citric acid (12.5 mM; 48 h) trisodium increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

くえん酸三ナトリウム 関連抗体

Cell Viability Assay[3]

Cell Line: HaCaT cells
Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM
Incubation Time: 24 h
Result: Inhibited the cell viability in a dose dependent manner.

Cell Cycle Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 0, 12, 24, 48, 72 h
Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.

Western Blot Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 12, 24, 48 h
Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
体内実験

Citric acid (120, 240, and 480 mg/kg; i.p.) trisodium significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1].
Citric acid (120, 240, and 480 mg/kg; i.p.) trisodium induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20 g male Kunming mice[2]
Dosage: 120, 240, 480 mg/kg
Administration: I.p.; weekly for 3 weeks
Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
分子量

258.07

分子式

C6H5Na3O7
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[Na].O=C(O)CC(O)(C(=O)O)CC(=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature, keep dry and cool

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)
溶剤 & 溶解度
体外: 

H2O : 50 mg/mL (193.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8749 mL 19.3746 mL 38.7492 mL
5 mM 0.7750 mL 3.8749 mL 7.7498 mL
10 mM 0.3875 mL 1.9375 mL 3.8749 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.95%

COA (250 KB) HNMR (115 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.8749 mL 19.3746 mL 38.7492 mL 96.8729 mL
5 mM 0.7750 mL 3.8749 mL 7.7498 mL 19.3746 mL
10 mM 0.3875 mL 1.9375 mL 3.8749 mL 9.6873 mL
15 mM 0.2583 mL 1.2916 mL 2.5833 mL 6.4582 mL
20 mM 0.1937 mL 0.9687 mL 1.9375 mL 4.8436 mL
25 mM 0.1550 mL 0.7750 mL 1.5500 mL 3.8749 mL
30 mM 0.1292 mL 0.6458 mL 1.2916 mL 3.2291 mL
40 mM 0.0969 mL 0.4844 mL 0.9687 mL 2.4218 mL
50 mM 0.0775 mL 0.3875 mL 0.7750 mL 1.9375 mL
60 mM 0.0646 mL 0.3229 mL 0.6458 mL 1.6145 mL
80 mM 0.0484 mL 0.2422 mL 0.4844 mL 1.2109 mL
100 mM 0.0387 mL 0.1937 mL 0.3875 mL 0.9687 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Citric acid trisodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Citric acid trisodium68-04-2SodiumTrisodium citrateEnvironmental PollutantsBacterialEndogenous MetaboliteApoptosisEnvironmental Contaminantsantioxidativeapoptosisrenal toxicityMDA levelsmOxidative damageG2/M phaseS phaseHaCaT cellsInhibitorinhibitorinhibit

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