Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid

Cat. No.: HY-176972: Fiche technique Instruction de manipulation
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Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid (Compound 5) is a cytotoxic pyrrolobenzodiazepine (PBD) dimer derivative. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid exhibits moderate DNA alkylating activity. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid can be used as the payload of ADC, thereby demonstrating strong antigen-dependent cytotoxicity.

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Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid Chemical Structure

CAS No. : 3037777-07-1

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Description	Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid (Compound 5) is a cytotoxic pyrrolobenzodiazepine (PBD) dimer derivative. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid exhibits moderate DNA alkylating activity. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid can be used as the payload of ADC, thereby demonstrating strong antigen-dependent cytotoxicity^[1].
Masse moléculaire	736.79
Formule	C₃₉H₃₆N₄O₉S
CAS No.	3037777-07-1
SMILES	O=C1C2=CC(OC)=C(OCC3=CC(COC4=C(C=C5C(N=C[C@@]6([H])N(CC(C6)=C)C5=O)=C4)OC)=CC(C#CCS(=O)(O)=O)=C3)C=C2N=C[C@@]7([H])N1CC(C7)=C
Livraison	Room temperature in continental US; may vary elsewhere.
Stockage	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation	Fiche technique (269 KB) Instruction de manipulation (2659 KB)
Références	[1]. Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63(17):9603-9622. [Content Brief]