Enduracidin  (Synonyms: Enramycin)

Enduracidin (Enramycin) is a polypeptide antibiotic produced by Streptomyces fungicides^[1].

Enduracidin has antibacterial activity against multiple antibiotic-resistant Staphylococci strains^[2].
Enduracidin inhibits peptidoglycan synthesis in M. lysodeikticus, Staphylococcus aureus, and E. coli^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enduracidin (s.c.; at 60 min post-infection) achieves a 50% survival rate with an ED₅₀ of 2.27 mg/kg in a mouse model of intravenous Staphylococcus aureus infection^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

11115-82-5

Solid

Light brown to brown

[Enduracidin]

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Y-W Chen, et al. Characterization of Three Regulatory Genes Involved in Enduracidin Biosynthesis and Improvement of Enduracidin Production in Streptomyces Fungicidicus. J Appl Microbiol. 2019 Dec;127(6):1698-1705.  [Content Brief]

  [2]. Kawakami M, et al. Anti-microbial activities of enduracidin (enramycin) in vitro and in vivo. J Antibiot (Tokyo). 1971 Sep;24(9):583-6.  [Content Brief]

  [3]. Matsuhashi M, et al. Inhibition of the Bacterial Cell Wall Synthesis in vitro by Enduracidin, a New Polypeptide Antibiotic. Agricultural and Biological Chemistry, 1969, 33(1): 134-137.