2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Estradiol enanthate

Estradiol enanthate  (Synonyms: E2EN)

製品番号: HY-B1830 純度: 98.07%
COA 取扱説明書 Technical Support

Estradiol enanthate (E2EN) is a shorter-acting estrogen. Estradiol enanthate is an injectable contraceptive in combination with Dihydroxyprogesterone acetophenide. Estradiol enanthate promotes withdrawal bleeding, in a pattern similar to menstruation.

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Estradiol enanthate

Estradiol enanthate 構造式

CAS 番号 : 4956-37-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $40 在庫あり
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Estradiol enanthate 関連抗体

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製品説明

Estradiol enanthate (E2EN) is a shorter-acting estrogen. Estradiol enanthate is an injectable contraceptive in combination with Dihydroxyprogesterone acetophenide. Estradiol enanthate promotes withdrawal bleeding, in a pattern similar to menstruation[1].

体内実験

Estradiol enanthate (10 mg, i.m., every 10 days for 5 months) changes the corporal characteristics of male rats similar to female rats and increases ratio of estradiol/testosterone in combination with 150 mg of Dihydroxyprogesterone acetophenide[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Two-month old male and female Wistar rats[2]
Dosage: 10 mg, every 10 days for 5 months, in combination with 150 mg of Dihydroxyprogesterone acetophenide
Administration: Intramuscular injection (i.m.)
Result: Reduced body weight of male rats and was similar to female rats.
Diminished both hematocrit and hemoglobin in male rats.
Did not alter hepatic enzyme AST and ALT range.
Markedly increase the daily food and water intake.
Did not alter systolic blood pressure and glomerular filtration rate in male rats after 5 months.
Reduced proteinuria in all male rats compared to female rats.
Increased plasma urea and creatinine concentration compared to control group.
分子量

384.55

分子式

C25H36O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@H](OC(CCCCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (325.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 100 mg/mL (260.04 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6004 mL 13.0022 mL 26.0044 mL
5 mM 0.5201 mL 2.6004 mL 5.2009 mL
10 mM 0.2600 mL 1.3002 mL 2.6004 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.50 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.6004 mL 13.0022 mL 26.0044 mL 65.0111 mL
5 mM 0.5201 mL 2.6004 mL 5.2009 mL 13.0022 mL
10 mM 0.2600 mL 1.3002 mL 2.6004 mL 6.5011 mL
15 mM 0.1734 mL 0.8668 mL 1.7336 mL 4.3341 mL
20 mM 0.1300 mL 0.6501 mL 1.3002 mL 3.2506 mL
25 mM 0.1040 mL 0.5201 mL 1.0402 mL 2.6004 mL
30 mM 0.0867 mL 0.4334 mL 0.8668 mL 2.1670 mL
40 mM 0.0650 mL 0.3251 mL 0.6501 mL 1.6253 mL
50 mM 0.0520 mL 0.2600 mL 0.5201 mL 1.3002 mL
60 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0835 mL
80 mM 0.0325 mL 0.1625 mL 0.3251 mL 0.8126 mL
100 mM 0.0260 mL 0.1300 mL 0.2600 mL 0.6501 mL
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Estradiol enanthate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estradiol enanthate4956-37-0E2ENEstrogen Receptor/ERREstrogencontraceptivedihydroxyprogesterone acetophenidehormoneInhibitorinhibitorinhibit

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