2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Eticlopride hydrochloride

Eticlopride (hydrochloride)  (Synonyms: エチクロプリド塩酸塩)

製品番号: HY-103413 純度: 99.45%
COA 取扱説明書 Technical Support

Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1-adrenergic, α2-adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride hydrochloride is an antipsychotic agent.

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Eticlopride hydrochloride

Eticlopride (hydrochloride) 構造式

CAS 番号 : 97612-24-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 在庫あり
Solution
10 mM * 1 mL in DMSO USD 132 在庫あり
Solid
5 mg $120 在庫あり
10 mg $190 在庫あり
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100 mg   お問い合わせ  

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Other Forms of Eticlopride hydrochloride:

Eticlopride (hydrochloride) 関連抗体

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製品説明

Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1-adrenergic, α2-adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride hydrochloride is an antipsychotic agent[1].

IC50 & Target

D2 Receptor

0.09 nM (Ki)

体外実験

Eticlopride (1 μM, 6 h) hydrochloride abrogates the action of DA, where DA increases KLF2 expression in HUVEC cells[2].
Eticlopride (1 μM, 15 min) hydrochloride abolishes heterodimerization of D2R/SSTR2 in rat striatal neurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eticlopride (hydrochloride) 関連抗体
体内実験

Eticlopride (10 mg/kg, i.p.) hydrochloride blocks normal vessel morphologyc restored by DA in orthotopic PC3 and HT29 tumor-bearing mice[2].
Eticlopride (0.01 or 0.02 mg/kg, i.p.) hydrochloride alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats treated with Ruinpirole (1 mg/kg) from postnatal days 1 to 21[4]
Dosage: 0.01 or 0.02 mg/kg
Administration: i.p.
Result: Alleviated cognitive deficits produced by neonatal quinpirole treatment in both male and female rats on the place version of the MWT, as well as in males tested on the match-to-place version of the MWT (MWT tested on P22 to P28).
分子量

377.31

分子式

C17H26Cl2N2O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC[C@H]1N(CC)CCC1)C2=C(O)C(CC)=CC(Cl)=C2OC.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 50 mg/mL (132.52 mM; Need ultrasonic)

DMSO : 50 mg/mL (132.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6503 mL 13.2517 mL 26.5034 mL
5 mM 0.5301 mL 2.6503 mL 5.3007 mL
10 mM 0.2650 mL 1.3252 mL 2.6503 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.45%

COA (251 KB) HNMR (278 KB) LCMS (260 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.6503 mL 13.2517 mL 26.5034 mL 66.2585 mL
5 mM 0.5301 mL 2.6503 mL 5.3007 mL 13.2517 mL
10 mM 0.2650 mL 1.3252 mL 2.6503 mL 6.6259 mL
15 mM 0.1767 mL 0.8834 mL 1.7669 mL 4.4172 mL
20 mM 0.1325 mL 0.6626 mL 1.3252 mL 3.3129 mL
25 mM 0.1060 mL 0.5301 mL 1.0601 mL 2.6503 mL
30 mM 0.0883 mL 0.4417 mL 0.8834 mL 2.2086 mL
40 mM 0.0663 mL 0.3313 mL 0.6626 mL 1.6565 mL
50 mM 0.0530 mL 0.2650 mL 0.5301 mL 1.3252 mL
60 mM 0.0442 mL 0.2209 mL 0.4417 mL 1.1043 mL
80 mM 0.0331 mL 0.1656 mL 0.3313 mL 0.8282 mL
100 mM 0.0265 mL 0.1325 mL 0.2650 mL 0.6626 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Eticlopride hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eticlopride97612-24-3Dopamine ReceptorBehavioral pharmacologyDopamine D2‐like receptorsExtrapyramidal side effectsInhibitorinhibitorinhibit

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