2. Others Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis NF-κB
  3. SOD Fluorescent Dye TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Environmental Pollutants
  4. Fluorene

Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders.

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Fluorene

Fluorene 화학구조

CAS No. : 86-73-7

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
500 mg 해외재고보유
1 g 해외재고보유
5 g   견적 받기  
10 g   견적 받기  

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고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Fluorene:

Fluorene Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fluorene

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders[1][2][3].

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
>50 μM
Compound: Fluorene
Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 32726747]
In Vitro

Fluorene (200-800 μM, 24-48 hours) induces oxidative stress and inflammation in A549 cells, characterized by increased ROS generation, enhanced lipid peroxidation, altered antioxidant enzyme activity, and upregulated TNF-α and IL-6 expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fluorene Related Antibodies

Western Blot Analysis[1]

Cell Line: A549 human lung epithelial cells (lung injury)
Concentration: 200, 400, 600, 800 μM
Incubation Time: 24 hours, 48 hours
Result: Upregulated TNF-α and IL-6 mRNA and protein expression levels. Additionally, SP-A expression increased in Fluorene-treated groups (400 and 600 μM) but decreased in the PAH mixture-treated group (600 μM).

Cell Viability Assay[1]

Cell Line: A549 human lung epithelial cells (lung injury)
Concentration: 200, 400, 600, 800 μM
Incubation Time: 24 hours, 48 hours
Result: Induced ROS generation in A549 cells, increased MDA content, and enhanced SOD and CAT activity.
In Vivo

Fluorene (100 mg/kg, p.o. or i.p., once daily for 60 days) decreases weight gain and increases relative liver weight in Wistar rats, with the i.p. route resulting in higher blood and brain levels of Fluorene and its metabolites[3].
Fluorene (1, 10 mg/kg/day, p.o. or i.p., once daily for 60 days) reduces anxiety levels in Wistar rats without affecting locomotor activity or learning ability[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fluorene oral or intraperitoneal (i.p.) administration-induced body weight and organ changes in Wistar rats[1]
Dosage: 1, 10, 100 mg/kg
Administration: Oral gavage (p.o.) or intraperitoneal injection (i.p.), once daily for 60 days
Result: Exhibited significantly reduced weight gain after 28 days and increased relative liver weight (The 100 mg/kg group). Additionally, higher concentrations of Fluorene and its hydroxylated metabolites were detected in the blood and brain of i.p.-treated rats compared to p.o.-treated ones.
Reduced anxiety levels in rats (1, 10 mg/kg), while the high dose (100 mg/kg) showed no significant changes. No effects on locomotor activity or learning ability were observed.
분자량

166.22

화학식

C13H10
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

C1(C=CC=C2)=C2CC3=C1C=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

RT, protect from light

In solvent -80°C 1 year
-20°C 6 months
용액&용해도
In Vitro: 

DMSO : 62.5 mg/mL (376.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0161 mL 30.0806 mL 60.1612 mL
5 mM 1.2032 mL 6.0161 mL 12.0322 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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순도&문서

Purity: 99.35%

SDS (623 KB)

COA (254 KB) HNMR (128 KB) RP-HPLC (331 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.0161 mL 30.0806 mL 60.1612 mL 150.4031 mL
5 mM 1.2032 mL 6.0161 mL 12.0322 mL 30.0806 mL
10 mM 0.6016 mL 3.0081 mL 6.0161 mL 15.0403 mL
15 mM 0.4011 mL 2.0054 mL 4.0107 mL 10.0269 mL
20 mM 0.3008 mL 1.5040 mL 3.0081 mL 7.5202 mL
25 mM 0.2406 mL 1.2032 mL 2.4064 mL 6.0161 mL
30 mM 0.2005 mL 1.0027 mL 2.0054 mL 5.0134 mL
40 mM 0.1504 mL 0.7520 mL 1.5040 mL 3.7601 mL
50 mM 0.1203 mL 0.6016 mL 1.2032 mL 3.0081 mL
60 mM 0.1003 mL 0.5013 mL 1.0027 mL 2.5067 mL
80 mM 0.0752 mL 0.3760 mL 0.7520 mL 1.8800 mL
100 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.5040 mL
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Fluorene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluorene86-73-7SODFluorescent DyeTNF ReceptorInterleukin RelatedReactive Oxygen Species (ROS)Environmental PollutantsSuperoxide DismutaseTumor Necrosis Factor ReceptorTNFRILEnvironmental ContaminantsPAHdyeprecursorpolycyclic aromatic hydrocarbonWistar ratsA549 human lung epithelial cells (lung injury)ROSTNF-αoxidative stressInhibitorinhibitorinhibit

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상품명:
Fluorene
Cat. No.:
HY-W026772
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