2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. GDC-0310

GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7.

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GDC-0310

GDC-0310 構造式

CAS 番号 : 1788063-52-4

容量 価格（税別） 在庫状況 数量
5 mg $500 在庫あり
10 mg $850 在庫あり
25 mg $1650 在庫あり
50 mg $2600 在庫あり
100 mg $4200 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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GDC-0310 関連抗体

Top Publications Citing Use of Products

Sodium Channel アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7[1].

IC50 & Target[1]

hNav1.4

3.4 nM (IC50)

hNav1.2

38 nM (IC50)

hNav1.6

198 nM (IC50)

hNav1.1

202 nM (IC50)

hNav1.5

551 nM (IC50)

Nav1.7

0.6 nM (IC50)

体外実験

GDC-0310 exhibits an EC50 of 1.1 μM in vivo and a Ki of 1.8 nM for Nav1.7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GDC-0310 関連抗体
体内実験

GDC-0310 shows substantially improved Nav selectivity and ADME properties[1].
GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

543.48

分子式

C25H29Cl2FN2O4S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(NS(=O)(C)=O)C1=CC(C2CC2)=C(OCC3CCN([C@H](C4=CC(Cl)=CC(Cl)=C4)C)CC3)C=C1F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 4 mg/mL (7.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8400 mL 9.2000 mL 18.3999 mL
5 mM 0.3680 mL 1.8400 mL 3.6800 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8400 mL 9.2000 mL 18.3999 mL 45.9999 mL
5 mM 0.3680 mL 1.8400 mL 3.6800 mL 9.2000 mL
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GDC-0310 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GDC-03101788063-52-4GDC0310GDC 0310Sodium ChannelNa channelsNa+ channelspainNav1.7Inhibitorinhibitorinhibit

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製品名:
GDC-0310
製品番号:
HY-139081
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