2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Interleukin Related NADPH Oxidase
  4. Hidrosmin

Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus.

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Hidrosmin

Hidrosmin 화학구조

CAS No. : 115960-14-0

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg   견적 받기  
50 mg   견적 받기  

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고객리뷰

Based on 1 Customer Validation

Other Forms of Hidrosmin:

Hidrosmin Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

View All NADPH Oxidase Isoform Specific Products:

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NOX1 NOX2 NOX4 NOX5 DUOX1

  • Biological Activity

  • 순도&문서

  • References

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제품 설명

Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus[1].

IC50 & Target

IL-1β

 

NOX1

 

NOX4

 

In Vitro

Hidrosmin (0.1-1 mM) downregulates the cytokine expression in renal cells exposed to high-glucose and/or inflammatory conditions and also modulates redox balance genes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hidrosmin Related Antibodies

RT-PCR[1]

Cell Line: HK2 cells
Concentration: 0.1, 0.3, 1 mM
Incubation Time: pretreated for 90 min with hidrosmin before stimulation with either high-glucose (30 mM D-Glucose (HY-B0389)) for 24 h, or a combination of human cytokines interleukin-6 (IL-6, 102 U/mL) and interfero
Result: Reduced the gene expression of CC chemokines (CCL2 and CCL5) and proinflammatory cytokines (IL-1β and TNFα) induced by 24 h high-glucose stimulation. Restored the expression of redox balance genes by preventing the prooxidant enzyme NADPH oxidase (NOX1 and NOX4 isoforms) and promoting the expression of antioxidant enzymes Superoxide dismutase-1 (SOD1) and Catalase (CAT) in HK2 cells exposed to high-glucose, as well as to cytokines.
In Vivo

Hidrosmin (300 mg/kg, Orally through the feeding, once daily for 7 weeks) ameliorates renal damage in diabetic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ApoE KO mice (14-16-week-old, induced T1D by streptozotocin injection)[1]
Dosage: 300 mg/kg/day, dissolved in tap water
Administration: Orally through the feeding, once daily for 7 weeks (hidrosmin solution were renewed every 2-3 days)
Result: Did not modify body weight, glycemia, and other biochemical parameters in diabetic mice, except for total cholesterol and low-density lipoprotein (LDL)-cholesterol, which presented a significant reduction when compared with the control group. Ameliorated renal dysfunction by reducing UACR levels. Showed a significant decrease in the urinary KIM-1 levels.
분자량

652.60

화학식

C30H36O16
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCCOC1=C2C(OC(C3=CC(O)=C(C=C3)OC)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
순도&문서
References
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Hidrosmin Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hidrosmin115960-14-0Interleukin RelatedNADPH OxidaseILNOXDiabetes mellitusdiabetic nephropathynephroprotectiveOrally activeInhibitorinhibitorinhibit

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상품명:
Hidrosmin
Cat. No.:
HY-105946
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