Indimitecan (Synonyms: LMP776)

Name: Indimitecan
Brand: MedChemExpress
SKU: HY-18350
Rating: 4.5 (0 reviews)

Cat. No.: HY-18350 Purity: 98.30%: Data Sheet
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Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.

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Indimitecan 화학구조

CAS No. : 915360-05-3

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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고객리뷰

Based on 1 Customer Validation

Other Forms of Indimitecan:

Indimitecan hydrochloride 견적 받기

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View All Topoisomerase Isoform Specific Products:

View All Isoforms

Topoisomerase Topo I Topo II DNA gyrase

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities^[1].

IC₅₀ & Target

Top1

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	< 0.01 3 Compound: 6	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 20630766]
DU-145	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human DU145 cells by SRB assay Antiproliferative activity against human DU145 cells by SRB assay	[PMID: 21710981]
DU-145	GI₅₀	<0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human DU145 cells by SRB assay Antiproliferative activity against human DU145 cells by SRB assay	[PMID: 21710981]
DU-145	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human DU145 cells by SRB assay Antiproliferative activity against human DU145 cells by SRB assay	[PMID: 21710981]
DU-145	GI₅₀	<0.01 3 Compound: 6	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 20630766]
HCT-116	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human HCT116 cells by SRB assay Antiproliferative activity against human HCT116 cells by SRB assay	[PMID: 21710981]
HCT-116	GI₅₀	< 0.01 3 Compound: 6	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 20630766]
HOP-62	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human HOP62 cells by SRB assay Antiproliferative activity against human HOP62 cells by SRB assay	[PMID: 21710981]
HCT-116	GI₅₀	<0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human HCT116 cells by SRB assay Antiproliferative activity against human HCT116 cells by SRB assay	[PMID: 21710981]
HCT-116	GI₅₀	<0.01 3 Compound: 6	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 20630766]
L1210	EC₅₀	0.06 3 Compound: 19	Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream forms infected in mouse L1210 cells after 48 hrs Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream forms infected in mouse L1210 cells after 48 hrs	[PMID: 18824603]
HCT-116	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human HCT116 cells by SRB assay Antiproliferative activity against human HCT116 cells by SRB assay	[PMID: 21710981]
HOP-62	GI₅₀	< 0.01 3 Compound: 6	Cytotoxicity against human HOP62 cells Cytotoxicity against human HOP62 cells	[PMID: 20630766]
MCF7	GI₅₀	0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human MCF7 cells by SRB assay Antiproliferative activity against human MCF7 cells by SRB assay	[PMID: 21710981]
HOP-62	GI₅₀	<0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human HOP62 cells by SRB assay Antiproliferative activity against human HOP62 cells by SRB assay	[PMID: 21710981]
HOP-62	GI₅₀	<0.01 3 Compound: 6	Cytotoxicity against human HOP62 cells Cytotoxicity against human HOP62 cells	[PMID: 20630766]
HOP-62	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human HOP62 cells by SRB assay Antiproliferative activity against human HOP62 cells by SRB assay	[PMID: 21710981]
OVCAR-3	GI₅₀	0.085 3 Compound: 7, indimitecan	Antiproliferative activity against human OVCAR3 cells by SRB assay Antiproliferative activity against human OVCAR3 cells by SRB assay	[PMID: 21710981]
L1210	EC₅₀	0.06 3 Compound: 19	Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream forms infected in mouse L1210 cells after 48 hrs Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream forms infected in mouse L1210 cells after 48 hrs	[PMID: 18824603]
SF-539	GI₅₀	0.037 3 Compound: 7, indimitecan	Antiproliferative activity against human SF539 cells by SRB assay Antiproliferative activity against human SF539 cells by SRB assay	[PMID: 21710981]
L1210	EC₅₀	0.06 3 Compound: 19	Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream forms infected in mouse L1210 cells after 48 hrs Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream forms infected in mouse L1210 cells after 48 hrs	[PMID: 18824603]
MCF7	GI₅₀	0.01 3 Compound: 6	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 20630766]
SN12C	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human SN12C cells by SRB assay Antiproliferative activity against human SN12C cells by SRB assay	[PMID: 21710981]
MCF7	GI₅₀	0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human MCF7 cells by SRB assay Antiproliferative activity against human MCF7 cells by SRB assay	[PMID: 21710981]
MCF7	GI₅₀	0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human MCF7 cells by SRB assay Antiproliferative activity against human MCF7 cells by SRB assay	[PMID: 21710981]
UACC-62	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human UACC62 cells by SRB assay Antiproliferative activity against human UACC62 cells by SRB assay	[PMID: 21710981]
MCF7	GI₅₀	0.01 3 Compound: 6	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 20630766]
OVCAR-3	GI₅₀	0.085 3 Compound: 6	Cytotoxicity against human OVCAR-3 cells Cytotoxicity against human OVCAR-3 cells	[PMID: 20630766]
OVCAR-3	GI₅₀	0.085 3 Compound: 7, indimitecan	Antiproliferative activity against human OVCAR3 cells by SRB assay Antiproliferative activity against human OVCAR3 cells by SRB assay	[PMID: 21710981]
OVCAR-3	GI₅₀	0.085 3 Compound: 7, indimitecan	Antiproliferative activity against human OVCAR3 cells by SRB assay Antiproliferative activity against human OVCAR3 cells by SRB assay	[PMID: 21710981]
OVCAR-3	GI₅₀	0.085 3 Compound: 6	Cytotoxicity against human OVCAR-3 cells Cytotoxicity against human OVCAR-3 cells	[PMID: 20630766]
SF-539	GI₅₀	0.037 3 Compound: 6	Cytotoxicity against human SF539 cells Cytotoxicity against human SF539 cells	[PMID: 20630766]
SF-539	GI₅₀	0.037 3 Compound: 7, indimitecan	Antiproliferative activity against human SF539 cells by SRB assay Antiproliferative activity against human SF539 cells by SRB assay	[PMID: 21710981]
SF-539	GI₅₀	0.037 3 Compound: 7, indimitecan	Antiproliferative activity against human SF539 cells by SRB assay Antiproliferative activity against human SF539 cells by SRB assay	[PMID: 21710981]
SF-539	GI₅₀	0.037 3 Compound: 6	Cytotoxicity against human SF539 cells Cytotoxicity against human SF539 cells	[PMID: 20630766]
SN12C	GI₅₀	< 0.01 3 Compound: 6	Cytotoxicity against human SN12C cells Cytotoxicity against human SN12C cells	[PMID: 20630766]
SN12C	GI₅₀	<0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human SN12C cells by SRB assay Antiproliferative activity against human SN12C cells by SRB assay	[PMID: 21710981]
SN12C	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human SN12C cells by SRB assay Antiproliferative activity against human SN12C cells by SRB assay	[PMID: 21710981]
SN12C	GI₅₀	<0.01 3 Compound: 6	Cytotoxicity against human SN12C cells Cytotoxicity against human SN12C cells	[PMID: 20630766]
UACC-62	GI₅₀	< 0.01 3 Compound: 6	Cytotoxicity against human UACC62 cells Cytotoxicity against human UACC62 cells	[PMID: 20630766]
UACC-62	GI₅₀	<0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human UACC62 cells by SRB assay Antiproliferative activity against human UACC62 cells by SRB assay	[PMID: 21710981]
UACC-62	GI₅₀	< 0.01 3 Compound: 7, indimitecan	Antiproliferative activity against human UACC62 cells by SRB assay Antiproliferative activity against human UACC62 cells by SRB assay	[PMID: 21710981]
UACC-62	GI₅₀	<0.01 3 Compound: 6	Cytotoxicity against human UACC62 cells Cytotoxicity against human UACC62 cells	[PMID: 20630766]

In Vitro

Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM^[1].
Indimitecan shows potent DNA cleavage due to Top1 inhibition^[1].
Indimitecan can be substrates for metabolic ketone reductases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7
Concentration:	0-100 μM
Incubation Time:
Result:	Showed growth inhibition with GI₅₀s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM.

Clinical Trial

분자량

459.45

화학식

C₂₅H₂₁N₃O₆

CAS No.

915360-05-3

Appearance

Solid

Color

Brown to black

SMILES

O=C1C2=CC(OC)=C(OC)C=C2C3=C(C(C=C(OCO4)C4=C5)=C5C3=O)N1CCCN6C=NC=C6

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1765 mL	10.8826 mL	21.7652 mL
5 mM	0.4353 mL	2.1765 mL	4.3530 mL
10 mM	0.2177 mL	1.0883 mL	2.1765 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

순도&문서

Purity: 98.30%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (258 KB) HNMR (269 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1765 mL	10.8826 mL	21.7652 mL	54.4129 mL
	5 mM	0.4353 mL	2.1765 mL	4.3530 mL	10.8826 mL
	10 mM	0.2177 mL	1.0883 mL	2.1765 mL	5.4413 mL
	15 mM	0.1451 mL	0.7255 mL	1.4510 mL	3.6275 mL

Indimitecan Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indimitecan915360-05-3LMP776LMP 776LMP-776TopoisomeraseanticancerDNA cleavageInhibitorinhibitorinhibit

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Indimitecan (Synonyms: LMP776)

고객리뷰

Other Forms of Indimitecan:

Indimitecan Related Antibodies

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Topoisomerase Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Indimitecan Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Indimitecan Related Classifications

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SAFETY DATA SHEET (SDS)

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