915360-05-3
915360-05-3
Chemical Structure
Indimitecan
Synonym(s): LMP776
- CAS No.: 915360-05-3
- Formula:C25H21N3O6
- Molecular Weight:459.45
IUPAC Name: 6-(3-(1H-imidazol-1-yl)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione
InChIKey: GCILEJUNEYIABW-UHFFFAOYSA-N
SMILES: O=C1C2=CC(OC)=C(OC)C=C2C3=C(C(C=C(OCO4)C4=C5)=C5C3=O)N1CCCN6C=NC=C6
Biological Activity: Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Indimitecan | 98.30% | Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-18350AIndimitecan hydrochloride -
Similarity Score 0.82
HY-18351Indotecan -
Similarity Score 0.81
HY-U00248LMP744 -
Similarity Score 0.81
HY-18351AIndotecan hydrochloride -
Similarity Score 0.81
HY-U00248ALMP744 hydrochloride -
Similarity Score 0.68
HY-160005LMP517 -
Similarity Score 0.56
HY-112126KRN5 -
Similarity Score 0.53
HY-16228Genz-644282 -
Similarity Score 0.53
HY-118942Topovale -
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References
- [1]. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. [Content Brief]
