1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. LMP744

LMP744 (Synonyms: MJ-III65; NSC706744)

Cat. No.: HY-U00248
Handling Instructions

LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

For research use only. We do not sell to patients.

LMP744 Chemical Structure

LMP744 Chemical Structure

CAS No. : 308246-52-8

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Description

LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

IC50 & Target[1]

Top1

 

In Vitro

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2].
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].

Cell Viability Assay[2]

Cell Line: P388 and P388 Top1-deficient murine leukemia cells
Concentration: 0.1-100 μM
Incubation Time: 3 days
Result: Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.
In Vivo

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1].
Dosage: 10, 25, or 50 mg/kg/week, 4 weeks
Administration: I.V. push via tail vein
Result: Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.
Clinical Trial
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

452.46

Formula

C₂₄H₂₄N₂O₇

CAS No.

308246-52-8

SMILES

OCCNCCCN1C2=C(C(C3=CC(OCO4)=C4C=C23)=O)C5=CC(OC)=C(OC)C=C5C1=O

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LMP744
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LMP744

Cat. No.: HY-U00248