1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. LMP744

LMP744 (Synonyms: MJ-III65; NSC706744)

Cat. No.: HY-U00248
Handling Instructions

LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

For research use only. We do not sell to patients.

LMP744 Chemical Structure

LMP744 Chemical Structure

CAS No. : 308246-52-8

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Description

LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

IC50 & Target[1]

Top1

 

In Vitro

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2].
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].

Cell Viability Assay[2]

Cell Line: P388 and P388 Top1-deficient murine leukemia cells
Concentration: 0.1-100 μM
Incubation Time: 3 days
Result: Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.
In Vivo

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1].
Dosage: 10, 25, or 50 mg/kg/week, 4 weeks
Administration: I.V. push via tail vein
Result: Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.
Clinical Trial
Molecular Weight

452.46

Formula

C₂₄H₂₄N₂O₇

CAS No.

308246-52-8

SMILES

OCCNCCCN1C2=C(C(C3=CC(OCO4)=C4C=C23)=O)C5=CC(OC)=C(OC)C=C5C1=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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