1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. LMP744 hydrochloride

LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride)

Cat. No.: HY-U00248A
Handling Instructions

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

For research use only. We do not sell to patients.

LMP744 hydrochloride Chemical Structure

LMP744 hydrochloride Chemical Structure

CAS No. : 308246-57-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 312 In-stock
Estimated Time of Arrival: December 31
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 290 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

IC50 & Target

Top1[1].

In Vitro

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2].
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].

Cell Cytotoxicity Assay[2]

Cell Line: P388 and P388 Top1-deficient murine leukemia cells.
Concentration: 0.1-100 μM
Incubation Time: 3 days
Result: Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.
In Vivo

LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1].
Dosage: 10, 25, or 50 mg/kg/week, 4 weeks
Administration: I.V. push via tail vein
Result: Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.56 mg/mL (11.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0453 mL 10.2266 mL 20.4532 mL
5 mM 0.4091 mL 2.0453 mL 4.0906 mL
10 mM 0.2045 mL 1.0227 mL 2.0453 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.56 mg/mL (1.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.56 mg/mL (1.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

488.92

Formula

C₂₄H₂₅ClN₂O₇

CAS No.

308246-57-3

SMILES

OCCNCCCN1C2=C(C(C3=CC(OCO4)=C4C=C23)=O)C5=CC(OC)=C(OC)C=C5C1=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
LMP744 hydrochloride
Cat. No.:
HY-U00248A
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LMP744 hydrochloride

Cat. No.: HY-U00248A