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Cat. No.: HY-18350A

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Indimitecan hydrochloride

(Synonyms: LMP776 hydrochloride)

Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities.

For research use only. We do not sell to patients.

CAS No.: 915303-04-7
Formula: C₂₅H₂₂ClN₃O₆
Molecular Weight:495.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Indimitecan hydrochloride Chemical Structure

CAS No.: 915303-04-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities^[1].

All Topoisomerase Isoforms :

Chemical Information

CAS No. 915303-04-7
Molecular Weight 495.91
Formula C₂₅H₂₂ClN₃O₆
SMILES

O=C1C2=C(C3=C1C4=CC(OC)=C(C=C4C(N3CCCN5C=NC=C5)=O)OC)C=C6OCOC6=C2.Cl
Synonyms

LMP776 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Indimitecan hydrochloride

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Indimitecan hydrochloride Related Classifications

HY-18350A Related Classifications