915303-04-7
915303-04-7
Chemical Structure
Indimitecan hydrochloride
Synonym(s): LMP776 hydrochloride
- CAS No.: 915303-04-7
- Formula:C25H22ClN3O6
- Molecular Weight:495.91
InChIKey: VZCPAXRDLDYWBE-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=C1C4=CC(OC)=C(C=C4C(N3CCCN5C=NC=C5)=O)OC)C=C6OCOC6=C2.Cl
Biological Activity: Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities[1].
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Indimitecan hydrochloride | Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities. | |||||||||||||||||||||
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References
- [1]. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. [Content Brief]
Keywords
