2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Indimitecan

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.

For research use only. We do not sell to patients.

Indimitecan Chemical Structure

Indimitecan Chemical Structure

CAS No. : 915360-05-3

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Based on 1 publication(s) in Google Scholar

Indimitecan Related Antibodies

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Topoisomerase Topo I Topo II

  • Biological Activity

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Description

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1].

IC50 & Target

Top1

 

In Vitro

Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM[1].
Indimitecan shows potent DNA cleavage due to Top1 inhibition[1].
Indimitecan can be substrates for metabolic ketone reductases[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Indimitecan Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7
Concentration: 0-100 μM
Incubation Time:
Result: Showed growth inhibition with GI50s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM.
Clinical Trial
Molecular Weight

459.45

Formula

C25H21N3O6
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C1C2=CC(OC)=C(OC)C=C2C3=C(C(C=C(OCO4)C4=C5)=C5C3=O)N1CCCN6C=NC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1765 mL 10.8826 mL 21.7652 mL
5 mM 0.4353 mL 2.1765 mL 4.3530 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.03%

COA (258 KB) HNMR (268 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1765 mL 10.8826 mL 21.7652 mL 54.4129 mL
5 mM 0.4353 mL 2.1765 mL 4.3530 mL 10.8826 mL
10 mM 0.2177 mL 1.0883 mL 2.1765 mL 5.4413 mL
15 mM 0.1451 mL 0.7255 mL 1.4510 mL 3.6275 mL
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Indimitecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indimitecan915360-05-3LMP776LMP 776LMP-776TopoisomeraseanticancerDNA cleavageInhibitorinhibitorinhibit

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