2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. LMP517

LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs.

For research use only. We do not sell to patients.

LMP517 Chemical Structure

LMP517 Chemical Structure

CAS No. : 1883730-99-1

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LMP517 Related Antibodies

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Description

LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs[1].

IC50 & Target

Topoisomerase I

 

Topoisomerase II

 

Molecular Weight

410.40

Formula

C22H19FN2O5
CAS No.
SMILES

O=C1C2=CC3=C(C=C2C4=C1C5=C(C(N4CCCNCCO)=O)C=C(F)C=C5)OCO3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LMP517 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LMP5171883730-99-1NSC 781517LMP 517LMP-517NSC781517NSC-781517TopoisomeraseInhibitorinhibitorinhibit

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