1883730-99-1
1883730-99-1
Chemical Structure
LMP517
Synonym(s): NSC 781517
- CAS No.: 1883730-99-1
- Formula:C22H19FN2O5
- Molecular Weight:410.40
InChIKey: YFHMWOJCGJARKT-UHFFFAOYSA-N
SMILES: O=C1C2=CC3=C(C=C2C4=C1C5=C(C(N4CCCNCCO)=O)C=C(F)C=C5)OCO3
Biological Activity: LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LMP517 | 99.20% | LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer. | ||||||||||||||||||||
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References
- [1]. Marzi L, et al. The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2. Mol Cancer Ther. 2020 Aug;19(8):1589-1597. [Content Brief]
- [2]. Marzi L, et al. Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors. Mol Cancer Ther. 2018 Aug;17(8):1694-1704. [Content Brief]
Keywords
