2. Others Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection Apoptosis NF-κB
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  4. Insect repellent M 3535

Insect repellent M 3535  (Synonyms: Ethyl butylacetylaminopropionate; IR-3535)

Art. -Nr.: HY-W099479 Reinheit: 98.44%
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Handling Instructions Technical Support

Insect repellent M 3535 (Ethyl butylacetylaminopropionate) is a broad-spectrum, mild insect repellent based on the structure of β-alanine. Insect repellent M 3535 exerts repellent effects by interfering with the olfaction of mosquitoes, but it poses risks of developmental and cardiac toxicity to aquatic organisms such as zebrafish embryos in aquatic environments, and can activate oxidative stress responses.

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Insect repellent M 3535

Insect repellent M 3535 Chemische Struktur

CAS. Nr. : 52304-36-6

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Insect repellent M 3535 Related Antibodies

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Beschreibung

Insect repellent M 3535 (Ethyl butylacetylaminopropionate) is a broad-spectrum, mild insect repellent based on the structure of β-alanine. Insect repellent M 3535 exerts repellent effects by interfering with the olfaction of mosquitoes, but it poses risks of developmental and cardiac toxicity to aquatic organisms such as zebrafish embryos in aquatic environments, and can activate oxidative stress responses[1][2].

In Vitro

The combination of Insect repellent M 3535 (10%; 30 min) and 1% supercritical cinnamon oil at a ratio of 1:1 exhibits aromatic repellent activity against Culex pipiens pallens[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Insect repellent M 3535 Related Antibodies
In Vivo

Insect repellent M 3535 (10-30 mg/L, immersion in aqueous solution; solution replaced daily; 5.5-72 h post fertilization) exerts dose-dependent developmental toxicity and cardiotoxicity on zebrafish embryos during the period from 5.5 hpf to 72 hpf, as well as activates the oxidative stress-mediated apoptotic pathway[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type zebrafish (Danio rerio) and transgenic lines Tg(myl7:GFP), Tg(myl7:GFP;gata1:Dsred)
[2]
Dosage: 10 mg/L, 20 mg/L, 30 mg/L
Administration: aquatic immersion; daily solution renewal; 5.5 hpf to 72 hpf
Result: Reduced body length, slowed yolk absorption, caused spinal curvature and pericardial edema, decreased heart rate, impaired cardiac looping and pumping function, dysregulated cardiac developmental genes (nkx2.5, myh6, tbx5a, vmhc, gata4, tbx2b).
Elevated ROS and MDA levels, lowered CAT and SOD activities, upregulated apoptosis‑related genes (bax/bcl2, p53, caspase9, caspase3), and triggered apoptosis.
Molekulargewicht

215.29

Formel

C11H21NO3
CAS. Nr.
Appearance

Liquid (Density: 0.988±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

CCCCN(CCC(=O)OCC)C(=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : ≥ 100 mg/mL (464.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6449 mL 23.2245 mL 46.4490 mL
5 mM 0.9290 mL 4.6449 mL 9.2898 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.91%

SDS (393 KB)

COA (243 KB) HNMR (116 KB) MS (300 KB) GC (177 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6449 mL 23.2245 mL 46.4490 mL 116.1224 mL
5 mM 0.9290 mL 4.6449 mL 9.2898 mL 23.2245 mL
10 mM 0.4645 mL 2.3224 mL 4.6449 mL 11.6122 mL
15 mM 0.3097 mL 1.5483 mL 3.0966 mL 7.7415 mL
20 mM 0.2322 mL 1.1612 mL 2.3224 mL 5.8061 mL
25 mM 0.1858 mL 0.9290 mL 1.8580 mL 4.6449 mL
30 mM 0.1548 mL 0.7741 mL 1.5483 mL 3.8707 mL
40 mM 0.1161 mL 0.5806 mL 1.1612 mL 2.9031 mL
50 mM 0.0929 mL 0.4645 mL 0.9290 mL 2.3224 mL
60 mM 0.0774 mL 0.3871 mL 0.7741 mL 1.9354 mL
80 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4515 mL
100 mM 0.0464 mL 0.2322 mL 0.4645 mL 1.1612 mL
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Insect repellent M 3535 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Insect repellent M 353552304-36-6Ethyl butylacetylaminopropionate IR-3535Insect repellent M3535Insect repellent M-3535IR3535IR 3535IR-3535ParasiteSODReactive Oxygen Species (ROS)Environmental PollutantsApoptosisSuperoxide DismutaseEnvironmental Contaminantsoxidative stresssuperoxide dismutaseCulex pipiens pallensAedes togoireactive oxygen speciescatalasezebrafish embryosfleasapoptosisAedes albopictusInhibitorinhibitorinhibit

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