2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. KIF18A-IN-1

KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells.

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KIF18A-IN-1

KIF18A-IN-1 構造式

CAS 番号 : 2600559-12-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 495 在庫あり
Solution
10 mM * 1 mL in DMSO USD 495 在庫あり
Solid
5 mg $390 在庫あり
10 mg $625 在庫あり
25 mg $1250 在庫あり
50 mg $2000 在庫あり
100 mg $3200 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

KIF18A-IN-1 関連抗体

Top Publications Citing Use of Products

Kinesin アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14 Kinesin-13

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製品説明

KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells[1][2].

IC50 & Target

KIF18A

 

体外実験

KIF18A-IN-1 (compound C9) has broad inhibitory activity against cancer cell lines, with IC50 values ??of 5.09 nM (MDA-MB-157), 12.4 nM (OVCAR-8), 6.11 nM (HCC-1806), 20.9 nM (HeLa), and 10.3 nM (OVCAR-3) after 5 days of treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIF18A-IN-1 関連抗体

Cell Viability Assay[1]

Cell Line: OVCAR-8
Concentration: 0 nM, 4 nM, 8 nM, 16 nM, 32 nM, 64 nM, 128 nM
Incubation Time: 5 days
Result: Exhibited the IC50 and IC90 values against OVACR-8 of 11 nM and 33 nM, respectivley.
分子量

576.77

分子式

C28H40N4O5S2
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(S(=O)(NC(C)(C)C)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(=O)(NC(C)(C)C)=O)=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (173.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7338 mL 8.6690 mL 17.3379 mL
5 mM 0.3468 mL 1.7338 mL 3.4676 mL
10 mM 0.1734 mL 0.8669 mL 1.7338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7338 mL 8.6690 mL 17.3379 mL 43.3448 mL
5 mM 0.3468 mL 1.7338 mL 3.4676 mL 8.6690 mL
10 mM 0.1734 mL 0.8669 mL 1.7338 mL 4.3345 mL
15 mM 0.1156 mL 0.5779 mL 1.1559 mL 2.8897 mL
20 mM 0.0867 mL 0.4334 mL 0.8669 mL 2.1672 mL
25 mM 0.0694 mL 0.3468 mL 0.6935 mL 1.7338 mL
30 mM 0.0578 mL 0.2890 mL 0.5779 mL 1.4448 mL
40 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0836 mL
50 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8669 mL
60 mM 0.0289 mL 0.1445 mL 0.2890 mL 0.7224 mL
80 mM 0.0217 mL 0.1084 mL 0.2167 mL 0.5418 mL
100 mM 0.0173 mL 0.0867 mL 0.1734 mL 0.4334 mL
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KIF18A-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIF18A-IN-12600559-12-2KinesinmitotickinesinKIF18AtumorInhibitorinhibitorinhibit

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製品名:
KIF18A-IN-1
製品番号:
HY-145034
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